Release kinetics of single pellets and the multi-pellet system of tamsulosin hydrochloride sustained release pellets
文献类型：期刊论文
| 作者 | Yang Shuo3; Wang Caifen1; Li Xue1; Li Ying1; Yin Xianzhen1; Guo Tao1; Zhang Jiwen1 ; He Jun3; Sun Lixin2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2014 |
| 卷号 | 49期号:4页码:535-542 |
| 关键词 | tamsulosin hydrochloride single pellet release kinetics LC/MS/MS multiple-unit drug delivery system particle system |
| ISSN号 | 0513-4870 |
| 其他题名 | 盐酸坦索罗辛缓释微丸的单颗粒及其颗粒群释放动力学研究 |
| 文献子类 | Article |
| 英文摘要 | The release behavior of single pellet was investigated by LC/MS/MS method with tamsulosin hydrochloride (TSH) as the model drug of the research and then the pellets were divided into four groups according to the drug loading. Comparison of dissolution profiles of each group and capsule were performed using f_1 and f_2 factor methods to study the difference and similarity. The release profiles of single pellet, each group and capsule were analyzed using principle component analysis (PCA). The particle system was built through Matlab to get the target release profile. The result of this research demonstrated the release behavior of single pellet correlated well with the drug loading. While the dissolution profile of capsule as a reference, the similarity factor of dissolution profiles of the lower drug loading groups were 62.2, 67.1, 53.9, respectively and, 43.3 for highest drug loading group. The particle systems with different pellet distribution and same release profiles were built through release behavior of single pellet. It is of significance to investigate the release behavior of single pellets for studying the release regularity of multiple-unit drug delivery system. |
| 资助项目 | 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5103287 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269343]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang Jiwen |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; 2.Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China. 3.Guizhou Province Biochemistry Engineering Center, Guiyang, Guizhou 550025, China.; |
| 推荐引用方式 GB/T 7714 | Yang Shuo,Wang Caifen,Li Xue,et al. Release kinetics of single pellets and the multi-pellet system of tamsulosin hydrochloride sustained release pellets[J]. Acta Pharmaceutica Sinica,2014,49(4):535-542. |
| APA | Yang Shuo.,Wang Caifen.,Li Xue.,Li Ying.,Yin Xianzhen.,...&Sun Lixin.(2014).Release kinetics of single pellets and the multi-pellet system of tamsulosin hydrochloride sustained release pellets.Acta Pharmaceutica Sinica,49(4),535-542. |
| MLA | Yang Shuo,et al."Release kinetics of single pellets and the multi-pellet system of tamsulosin hydrochloride sustained release pellets".Acta Pharmaceutica Sinica 49.4(2014):535-542. |
入库方式： OAI收割
来源：上海药物研究所
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