Transdermal and Biotramsformation Differences between Amindevulinic Acid Hydrochloride Solution and Gel Formula
文献类型：期刊论文
| 作者 | Guo Qianqian1; Liu Jinhua1; Liu Ergang2; Zhao Yongxing1; Hua Haiying2; Xue Yijun3; Huang Yongzhuo2 ; Jiang Jianping3; Su Yong3
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| 刊名 | Chinese Journal of Modern Applied Pharmacy
 |
| 出版日期 | 2014 |
| 卷号 | 31期号:1页码:57-60 |
| 关键词 | aminolevulinic acid hydrochloride transdermal absorption protoporphyrin |
| ISSN号 | 1007-7693 |
| 其他题名 | 盐酸氨酮戊酸溶液剂与水凝胶的透皮及体内转化效果评价 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To assess the transdermal and in vivo biotransformation behaveior of the topical applied aminolevulinic acid hydrochloride(ALA) in the dosage forms of solution and gel. METHODS Transdermal behevier of the two formulations was performed in diffusion cell; ALA converted protoporphyrin(PpIX) in mice skin was quantified as an index to assess the transformation efficiency of the two formulations. RESULTS The cumulative retained and permeated(Q) amount of ALA in pig skin, transdermal flux and lag time(T_L) of ALA solution were (52.689.95)mg·cm~(-2), (38.8315.70)mg·cm~(-2), (12.27 5.99)mg·cm~(-2)·h~(-1), and (0.700.35)h, respectively. The results from ALA gel were (59.9028.68)mg·cm~(-2), (41.91 18.80)mg·cm~(-2), (13.225.82)mg·cm~(-2)·h~(-1) and (0.800.32)h, respectively. PpIX converted from ALA was measured to be (2.140.22)mug·mg-1 for gel and (2.170.48)mug·mg-1 for solution. CONCLUSION There are no statistically differences between ALA gel and solution both in transdermal behevier and PpIX transformation efficiency, based on in vitro and in vivo experiments. Considerations should be given to formulation differences when clinical decisions being made. |
| 资助项目 | 重大新药创制国家科技重大专项[00000000] ; 上海市科研计划项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5048030 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269353]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; 3.Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co.,Ltd., Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Guo Qianqian,Liu Jinhua,Liu Ergang,et al. Transdermal and Biotramsformation Differences between Amindevulinic Acid Hydrochloride Solution and Gel Formula[J]. Chinese Journal of Modern Applied Pharmacy,2014,31(1):57-60. |
| APA | Guo Qianqian.,Liu Jinhua.,Liu Ergang.,Zhao Yongxing.,Hua Haiying.,...&Su Yong.(2014).Transdermal and Biotramsformation Differences between Amindevulinic Acid Hydrochloride Solution and Gel Formula.Chinese Journal of Modern Applied Pharmacy,31(1),57-60. |
| MLA | Guo Qianqian,et al."Transdermal and Biotramsformation Differences between Amindevulinic Acid Hydrochloride Solution and Gel Formula".Chinese Journal of Modern Applied Pharmacy 31.1(2014):57-60. |
入库方式： OAI收割
来源：上海药物研究所
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