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Simultaneous determination of gallic acid, 5-hydroxylmethyl furfural, morroniside, loganin, sweroside, paeonol and paeoniflorin in Liuwei Dihuang osmotic pump-controlled release tablets by HPLC

文献类型：期刊论文

作者Deng Zhenxue2; Zhao Jinlu2; Hu Rongfeng3; Zhang Jiwen1; Sun Lixin2
刊名Journal of Shenyang Pharmaceutical University
出版日期2013
卷号30期号:9页码:686
关键词Liuwei Dihuang osmotic pump-controlled release tablets RP-HPLC content determination
ISSN号1006-2858
其他题名RP-HPLC法同时测定六味地黄渗透泵片中没食子酸等7种活性成分的含量
文献子类Article
英文摘要Objective To develop an RP-HPLC method for simultaneous determination of gallic acid, 5-hydroxylmethyl furfural, morroniside, loganin, sweroside, paeonol and paeoniflorin in Liuwei Dihuang (traditional Chinese medicine) osmotic pump-controlled release tablets. Methods Isolation of sample was achieved on a Diamonsil C18 column (250 mm * 4.6 mm, 5 mum).The column temperature was maintained at 35 ℃ and detection wavelength was set at 254 nm. Solvent A (water, 0.06% phosphoric acid, V︰V) and solvent B (acetonitrile, 0.06% phosphoric acid, V︰V) were used for gradient elution. The flow rate was 1.0 mL·min~(-1). Results The linearity ranges of gallic acid, 5-hydroxylmethyl furfural, morroniside, loganin, sweroside, paeonol and paeoniflorin were 3.992-19.96 mg·L~(-1), 8.710-43.55 mg·L~(-1), 5.613-28.06 mg·L~(-1), 8.772-43.86 mg·L~(-1), 0.721 7-3.608 mg·L~(-1), 1.643-8.215 mg·L~(-1) and 14.60-73.00 mg·L~(-1), respectively (r≥0.999 7). The average recoveries (n=9) of them were 96.1%, 100.5%, 99.1%, 101.1%, 102.6%, 97.8% and 102.5%, respectively. Conclusions The method is simple, rapid and accurate. It can be applied for the quality control of Liuwei Dihuang osmotic pump-controlled release tablets.
资助项目国家自然科学基金资助项目[00000000] ; 辽宁省高校创新团队支持计划[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:4945556
源URL[http://119.78.100.183/handle/2S10ELR8/269368]  
专题药物制剂研究中心
作者单位1.Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China.
2.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.;
3.School of Pharmacy, Anhui College of Traditional Chinese Medicine, Hefei, Anhui 230038, China.;
推荐引用方式
GB/T 7714		 Deng Zhenxue,Zhao Jinlu,Hu Rongfeng,et al. Simultaneous determination of gallic acid, 5-hydroxylmethyl furfural, morroniside, loganin, sweroside, paeonol and paeoniflorin in Liuwei Dihuang osmotic pump-controlled release tablets by HPLC[J]. Journal of Shenyang Pharmaceutical University,2013,30(9):686.
APA Deng Zhenxue,Zhao Jinlu,Hu Rongfeng,Zhang Jiwen,&Sun Lixin.(2013).Simultaneous determination of gallic acid, 5-hydroxylmethyl furfural, morroniside, loganin, sweroside, paeonol and paeoniflorin in Liuwei Dihuang osmotic pump-controlled release tablets by HPLC.Journal of Shenyang Pharmaceutical University,30(9),686.
MLA Deng Zhenxue,et al."Simultaneous determination of gallic acid, 5-hydroxylmethyl furfural, morroniside, loganin, sweroside, paeonol and paeoniflorin in Liuwei Dihuang osmotic pump-controlled release tablets by HPLC".Journal of Shenyang Pharmaceutical University 30.9(2013):686.

入库方式： OAI收割

来源：上海药物研究所

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