Dissolving Microneedles Integrated With Liquid Crystals Facilitate Transdermal Delivery of Sinomenine Hydrochloride
文献类型：期刊论文
| 作者 | Gui, Zhiping1; Wu, Xingxing1; Wang, Shuyan5; Cao, Yingji1; Wan, Jun1; Shan, Qianqian1; Yang, Zhuanzhuan1; Zhang, Jiwen4 ; Gui, Shuangying1,2,3
|
| 刊名 | JOURNAL OF PHARMACEUTICAL SCIENCES
 |
| 出版日期 | 2017-12 |
| 卷号 | 106期号:12页码:3548-3555 |
| 关键词 | microarray transdermal drug delivery skin permeability pharmacokinetics biocompatibility |
| ISSN号 | 0022-3549 |
| DOI | 10.1016/j.xphs.2017.07.027 |
| 文献子类 | Article |
| 英文摘要 | The purpose of this study was to investigate the feasibility of delivering sinomenine hydrochloride (SH) transdermally using composite dissolving microneedles (DM) which integrated with liquid crystals (H-2). The fabricated SH-loaded composite DM was evaluated for their appearance, mechanical strength, irritation, and efficiency of transdermal delivery of SH. Results depicted that optimized SH-loaded composite DM had sufficient mechanical strength to pierce into rat skin. The in vitro permeability study in rat skin was successfully performed using Franz diffusion cell which showed that the cumulative permeation of SH in the composite DM were significantly increased compared with H-2 group (p < 0.05), and the penetration rate of SH in the composite DM kept constant during 48 h compared with DM group. The study of in vivo pharmacokinetics effects showed that the transdermal absorption of SH was enhanced and sustained by the SH-loaded composite DM compared with SH-loaded H-2 and SH-loaded DM. The skin irritation study in rats indicated that there were no irritation for normal skin, and the slight irritation for impaired skin recovered 24 h later. In conclusion, the novel composite DM may be a promising transdermal drug delivery system owing to its physical enhancing permeation function, drug reservoir effect, and biocompatibility. (C) 2017 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved. |
| WOS关键词 | COLLAGEN-INDUCED ARTHRITIS ; PHASE-BEHAVIOR ; DRUG-DELIVERY ; HEXAGONAL MESOPHASE ; IN-VITRO ; RELEASE ; PHYTANTRIOL ; RABBITS ; WATER ; DICLOFENAC |
| 资助项目 | National Natural Science Foundation of China[81274099] ; Exploratory Science Research Project Foundation of Anhui University of Traditional Chinese Medicine[2016ts06] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000417340700017 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272373]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gui, Shuangying |
| 作者单位 | 1.Anhui Univ Chinese Med, Dept Pharm, Hefei, Anhui, Peoples R China; 2.Minist Educ, Key Lab Xinan Med, Hefei, Anhui, Peoples R China 3.Anhui Acad Chinese Med, Inst Pharmaceut, Hefei, Anhui, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai, Peoples R China; 5.Soochow Univ, Coll Nano Sci & Technol, Suzhou, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Gui, Zhiping,Wu, Xingxing,Wang, Shuyan,et al. Dissolving Microneedles Integrated With Liquid Crystals Facilitate Transdermal Delivery of Sinomenine Hydrochloride[J]. JOURNAL OF PHARMACEUTICAL SCIENCES,2017,106(12):3548-3555. |
| APA | Gui, Zhiping.,Wu, Xingxing.,Wang, Shuyan.,Cao, Yingji.,Wan, Jun.,...&Gui, Shuangying.(2017).Dissolving Microneedles Integrated With Liquid Crystals Facilitate Transdermal Delivery of Sinomenine Hydrochloride.JOURNAL OF PHARMACEUTICAL SCIENCES,106(12),3548-3555. |
| MLA | Gui, Zhiping,et al."Dissolving Microneedles Integrated With Liquid Crystals Facilitate Transdermal Delivery of Sinomenine Hydrochloride".JOURNAL OF PHARMACEUTICAL SCIENCES 106.12(2017):3548-3555. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。