Remote Loading of Small-Molecule Therapeutics into Cholesterol-Enriched Cell-Membrane-Derived Vesicles
文献类型：期刊论文
| 作者 | Zhang, Xinxin1,2,3 ; Angsantikul, Pavimol2,3; Ying, Man2,3; Zhuang, Jia2,3; Zhang, Qiangzhe2,3; Wei, Xiaoli2,3; Jiang, Yao2,3; Zhang, Yue2,3; Dehaini, Diana2,3; Chen, Mengchun2,3
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| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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| 出版日期 | 2017-11-06 |
| 卷号 | 56期号:45页码:14075-14079 |
| 关键词 | biocompatibility biomimetic nanotechnology cell membrane drug delivery remote loading |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201707598 |
| 文献子类 | Article |
| 英文摘要 | The increasing popularity of biomimetic design principles in nanomedicine has led to therapeutic platforms with enhanced performance and biocompatibility. This includes the use of naturally derived cell membranes, which can bestow nanocarriers with cell-specific functionalities. Herein, we report on a strategy enabling efficient encapsulation of drugs via remote loading into membrane vesicles derived from red blood cells. This is accomplished by supplementing the membrane with additional cholesterol, stabilizing the nanostructure and facilitating the retention of a pH gradient. We demonstrate the loading of two model drugs: the chemotherapeutic doxorubicin and the antibiotic vancomycin. The therapeutic implications of these natural, remote-loaded nanoformulations are studied both in vitro and in vivo using animal disease models. Ultimately, this approach could be used to design new biomimetic nanoformulations with higher efficacy and improved safety profiles. |
| WOS关键词 | AMYLOID FIBRIL FORMATION ; PROTEIN AGGREGATION ; KINETICS ; NUCLEATION ; ATAXIN-3 ; PATHWAY ; MECHANISMS ; OLIGOMERS ; DISEASES ; MODEL |
| 资助项目 | Defense Threat Reduction Agency Joint Science and Technology Office for Chemical and Biological Defense[HDTRA1-16-1-0013] ; National Institutes of Health[R01CA200574] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000413896400028 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272411]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang, Liangfang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA; 3.Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA; |
| 推荐引用方式 GB/T 7714 | Zhang, Xinxin,Angsantikul, Pavimol,Ying, Man,et al. Remote Loading of Small-Molecule Therapeutics into Cholesterol-Enriched Cell-Membrane-Derived Vesicles[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2017,56(45):14075-14079. |
| APA | Zhang, Xinxin.,Angsantikul, Pavimol.,Ying, Man.,Zhuang, Jia.,Zhang, Qiangzhe.,...&Zhang, Liangfang.(2017).Remote Loading of Small-Molecule Therapeutics into Cholesterol-Enriched Cell-Membrane-Derived Vesicles.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,56(45),14075-14079. |
| MLA | Zhang, Xinxin,et al."Remote Loading of Small-Molecule Therapeutics into Cholesterol-Enriched Cell-Membrane-Derived Vesicles".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56.45(2017):14075-14079. |
入库方式： OAI收割
来源：上海药物研究所
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