Cyclodextrin-based metal-organic frameworks particles as efficient carriers for lansoprazole: Study of morphology and chemical composition of individual particles
文献类型：期刊论文
| 作者 | Li, Xue2,3; Guo, Tao3; Lachmanski, Laurent4; Manoli, Francesco1; Menendez-Miranda, Mario2; Manet, Ilse1; Guo, Zhen3; Wu, Li3; Zhang, Jiwen3 ; Gref, Ruxandra2
|
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2017-10-15 |
| 卷号 | 531期号:2页码:424-432 |
| 关键词 | Metal-organic frameworks CD-MOF gamma-cyclodextrin Raman spectroscopy Nanoparticle Individual particle characterization |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2017.05.056 |
| 文献子类 | Article |
| 英文摘要 | Cyclodextrin-based metal-organic frameworks (CD-MOFs) represent an environment-friendly and biocompatible class of MOFs drawing increasing attention in drug delivery. Lansoprazole (LPZ) is a proton-pump inhibitor used to reduce the production of acid in the stomach and recently identified as an antitubercular prodrug. Herein, LPZ loaded CD-MOFs were successfully synthesized upon the assembly with gamma-CD in the presence of K+ ions using an optimized co-crystallization method. They were characterized in terms of morphology, size and crystallinity, showing almost perfect cubic morphologies with monodispersed size distributions. The crystalline particles, loaded or not with LPZ, have mean diameters of around 6 mu m. The payloads reached 23.2 +/- 2.1% (wt) which corresponds to a molar ratio of 1:1 between LPZ and gamma-CD. It was demonstrated that even after two years storage, the incorporated drug inside the CD-MOFs maintained its spectroscopic characteristics. Molecular modelling provided a deeper insight into the interaction between the LPZ and CD-MOFs. Raman spectra of individual particles were recorded, confirming the formation of inclusion complexes within the tridimensional CD-MOF structures. Of note, it was found that each individual particle had the same chemical composition. The LPZ-loaded particles had remarkable homogeneity in terms of both drug loading and size. These results pave the way towards the use of CD-MOFs for drug delivery purposes. (C) 2017 Elsevier B.V. All rights reserved. |
| WOS关键词 | GAMMA-CYCLODEXTRIN ; DRUG ; STABILITY ; CURCUMIN |
| 资助项目 | "Cyclon Hit" project[608407] ; Natural Science Foundation of China[81430087] ; French National Research Agency (ANR) (Labex NanoSaclay)[ANR-10-LABX-0035] ; China scholarship council (CSC)[201408330166] ; [ANR-14-CE08-00177] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000413666800003 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272448]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang, Jiwen; Gref, Ruxandra |
| 作者单位 | 1.CNR, ISOF, Via P Gobetti 101, I-40129 Bologna, Italy 2.Paris Sud Univ, Inst Sci Mol Orsay, UMR CNRS 8214, Paris Saclay, F-91400 Orsay, France; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China; 4.Malvern Instruments, 30 Rue Jean Rostand, F-91405 Orsay, France; |
| 推荐引用方式 GB/T 7714 | Li, Xue,Guo, Tao,Lachmanski, Laurent,et al. Cyclodextrin-based metal-organic frameworks particles as efficient carriers for lansoprazole: Study of morphology and chemical composition of individual particles[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2017,531(2):424-432. |
| APA | Li, Xue.,Guo, Tao.,Lachmanski, Laurent.,Manoli, Francesco.,Menendez-Miranda, Mario.,...&Gref, Ruxandra.(2017).Cyclodextrin-based metal-organic frameworks particles as efficient carriers for lansoprazole: Study of morphology and chemical composition of individual particles.INTERNATIONAL JOURNAL OF PHARMACEUTICS,531(2),424-432. |
| MLA | Li, Xue,et al."Cyclodextrin-based metal-organic frameworks particles as efficient carriers for lansoprazole: Study of morphology and chemical composition of individual particles".INTERNATIONAL JOURNAL OF PHARMACEUTICS 531.2(2017):424-432. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。