Classification of microcrystalline celluloses via structures of individual particles measured by synchrotron radiation X-ray micro-computed tomography
文献类型：期刊论文
| 作者 | Fang, Longwei1,2; Yin, Xianzhen2,4; Wu, Li2; He, Yaping2,3; He, Yuanzhi2; Qin, Wei2; Meng, Fanyue2; York, Peter4; Xu, Xu1; Zhang, Jiwen1,2,3
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| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
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| 出版日期 | 2017-10-15 |
| 卷号 | 531期号:2页码:658-667 |
| 关键词 | Single particle Structural classification Microcrystalline cellulose Synchrotron radiation X-ray micro computed tomography Principal component analysis Partial least square discriminant analysis |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2017.05.019 |
| 文献子类 | Article |
| 英文摘要 | Microcrystalline cellulose (MCC) is one of the most important excipients due to its outstanding binding and tableting properties. Owing to the absence of high resolution characterization techniques at the single particle scale, 3D (three dimension) microstructure of MCC and its effects on formulation performance remain unexamined. The aim of this work was to establish a methodology for single particles of MCC type 102 based on synchrotron radiation X-ray micro computed tomography (SR-mCT), principal component analysis (PCA) and partial least square discriminant analysis (PLSDA). Scanning electron microscopy, SR-mCT, powders properties together with tensile strength (TS), disintegration time (DT), Kawakita plots and force/displacement profiles of tablets were measured. PCA-PLSDA was applied to evaluate the structural classification of MCC particles on the basis of 2D and 3D SR-mCT derived images. The studied MCCs were found to differ in the TS, DT, Kawakita plot and force/displacement, while box ratio and Feret ratio had major influence on the principal components, but the angle of repose, bulk and tapped density did not exhibit significantly. These findings verified that different samples of MCCs from alternative suppliers have morphological diversity when assessed at the individual particle level, which could result into variation in powder properties and tableting performance. (C) 2017 Elsevier B.V. All rights reserved. |
| WOS关键词 | DIRECT COMPRESSION ; FLOW PROPERTIES ; DRUG ; TABLETS ; MICROTOMOGRAPHY ; CRYSTALLINITY ; POWDERS ; VISUALIZATION ; FLOWABILITY ; FORMULATION |
| 资助项目 | National Natural Science Foundation of China[81430087] ; National Science and Technology Major Project[2017ZX09101-001] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000413666800026 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272449]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Xu, Xu; Zhang, Jiwen |
| 作者单位 | 1.Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England |
| 推荐引用方式 GB/T 7714 | Fang, Longwei,Yin, Xianzhen,Wu, Li,et al. Classification of microcrystalline celluloses via structures of individual particles measured by synchrotron radiation X-ray micro-computed tomography[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2017,531(2):658-667. |
| APA | Fang, Longwei.,Yin, Xianzhen.,Wu, Li.,He, Yaping.,He, Yuanzhi.,...&Zhang, Jiwen.(2017).Classification of microcrystalline celluloses via structures of individual particles measured by synchrotron radiation X-ray micro-computed tomography.INTERNATIONAL JOURNAL OF PHARMACEUTICS,531(2),658-667. |
| MLA | Fang, Longwei,et al."Classification of microcrystalline celluloses via structures of individual particles measured by synchrotron radiation X-ray micro-computed tomography".INTERNATIONAL JOURNAL OF PHARMACEUTICS 531.2(2017):658-667. |
入库方式： OAI收割
来源：上海药物研究所
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