Application of Monodisperse PEGs in Pharmaceutics: Monodisperse Polidocanols
文献类型：期刊论文
| 作者 | Yu, Zeqiong1; Bo, Shaowei1; Wang, Huiyuan2 ; Li, Yu1; Yang, Zhigang1; Huang, Yongzhuo2; Jiang, Zhong-Xing1,3
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| 刊名 | MOLECULAR PHARMACEUTICS
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| 出版日期 | 2017-10 |
| 卷号 | 14期号:10页码:3473-3479 |
| 关键词 | monodisperse polydisperse polyethylene glycols (PEGs) polidocanol PEGylated drugs |
| ISSN号 | 1543-8384 |
| DOI | 10.1021/acs.molpharmaceut.7b00496 |
| 文献子类 | Article |
| 英文摘要 | Polydisperse PEGs are ubiquitously used in pharmaceutical industry and biomedical research. However, the monodispersity in PEGs may play a role in the development of safe and effective PEGylated small molecular drugs. Here, to avoid the polydispersity in polidocanol, the active ingredient in a clinically used drug, a macro cyclic sulfate-based strategy for the efficient and scalable synthesis of monodisperse polidocanols, their sulfates, and their methylated derivatives, was developed. TLC and HPLC analysis indicated a complex mixture in regular polidocanol and high purifies in monodisperse polidocanols and their derivatives. Assay on HUVEC, L929, and HePG2. cells showed-that monodisperse polidocanols have much higher cytotoxicity and safety than that of regular polidocanol. It was found that the monodispersity of PEGs in polidocanols is crucial for achieving the optimal therapeutic results. Therefore, based on this case study, it would be beneficial to optimize PEGylated small molecular drugs with monodisperse PEGs in pharmaceutical research and development. |
| WOS关键词 | POLY(ETHYLENE GLYCOLS) ; DRUG-DELIVERY ; PEGYLATION ; DERIVATIVES ; HOMOSTARS |
| 资助项目 | National Key Research and Development Program of China[2016YFC1304704] ; National Natural Science Foundation of China[21372181] ; National Natural Science Foundation of China[21402144] ; National Natural Science Foundation of China[21572168] ; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials (Donghua University)[00000000] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000412379100023 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272469]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Jiang, Zhong-Xing |
| 作者单位 | 1.Wuhan Univ, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Hai Ke Rd, Shanghai 201203, Peoples R China; 3.Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Zeqiong,Bo, Shaowei,Wang, Huiyuan,et al. Application of Monodisperse PEGs in Pharmaceutics: Monodisperse Polidocanols[J]. MOLECULAR PHARMACEUTICS,2017,14(10):3473-3479. |
| APA | Yu, Zeqiong.,Bo, Shaowei.,Wang, Huiyuan.,Li, Yu.,Yang, Zhigang.,...&Jiang, Zhong-Xing.(2017).Application of Monodisperse PEGs in Pharmaceutics: Monodisperse Polidocanols.MOLECULAR PHARMACEUTICS,14(10),3473-3479. |
| MLA | Yu, Zeqiong,et al."Application of Monodisperse PEGs in Pharmaceutics: Monodisperse Polidocanols".MOLECULAR PHARMACEUTICS 14.10(2017):3473-3479. |
入库方式： OAI收割
来源：上海药物研究所
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