A mannosylated PEI-CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy
文献类型：期刊论文
| 作者 | Pan, Zhenzhen1,4,5; Kang, Xuejia1,5; Zeng, Yuaner1; Zhang, Wenyuan5; Peng, Huige5; Wang, Jinyu3,5; Huang, Wei5; Wang, Huiyuan5 ; Shen, Youqing2; Huang, Yongzhuo5
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| 刊名 | POLYMER CHEMISTRY
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| 出版日期 | 2017-09-21 |
| 卷号 | 8期号:35页码:5275-5285 |
| ISSN号 | 1759-9954 |
| DOI | 10.1039/c7py00882a |
| 文献子类 | Article |
| 英文摘要 | Polyethylenimine (PEI) is the most widely applied polymeric vector in gene delivery. However, its therapeutic application is hampered by the high cytotoxicity and poor in vivo transfection efficiency. We constructed a mannosylated, bioreducible hybrid of low-molecular-weight PEI and cell-penetrating peptide (termed Man-PEI5k-CPP) as a vector to deliver plasmid TRAIL (pTRAIL) for colorectal cancer treatment. We discovered that the colon cancer cells overexpressed mannose receptors (MR). With the combined functions of the tumor-targeting ligand and the CPP, the Man-PEI5k-CPP not only increased the cellular uptake efficiency, but also improved the efficiency of transfection, thus yielding enhanced inhibition efficacy on HCT116 human colon cancer cells, compared to the conventional PEI25k. The animal studies further confirmed the treatment success of Man-PEI5k-CPP/pTRAIL in the mice bearing xenografted HCT116 tumors and showed minimal systemic toxicity. |
| WOS关键词 | APOPTOSIS-INDUCING LIGAND ; PRODRUG-LIKE ; NANOPARTICLES ; REVERSAL ; CHITOSAN ; PROTEIN ; VECTOR |
| 资助项目 | 973 Program, China[2014CB931900] ; NFSC[81402883] ; NFSC[81673382] ; NFSC[81521005] ; NFSC[81422048] ; Scientific Research and Equipment Development Project[YZ201437] ; Youth Innovation Promotion Association[00000000] |
| WOS研究方向 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000411268700003 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272480]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Wang, Huiyuan; Huang, Yongzhuo |
| 作者单位 | 1.Guangzhou Univ Chinese Med, Guangzhou 501450, Peoples R China; 2.Zhejiang Univ, Coll Chem & Biol Engn, Hangzhou 310027, Zhejiang, Peoples R China 3.Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China; 4.Guangxi Univ Chinese Med, Fac Pharm, Guangxi Coll & Univ Key Lab Chinese Med Extract P, Nanning 530200, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Hai Ke Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Pan, Zhenzhen,Kang, Xuejia,Zeng, Yuaner,et al. A mannosylated PEI-CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy[J]. POLYMER CHEMISTRY,2017,8(35):5275-5285. |
| APA | Pan, Zhenzhen.,Kang, Xuejia.,Zeng, Yuaner.,Zhang, Wenyuan.,Peng, Huige.,...&Huang, Yongzhuo.(2017).A mannosylated PEI-CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy.POLYMER CHEMISTRY,8(35),5275-5285. |
| MLA | Pan, Zhenzhen,et al."A mannosylated PEI-CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy".POLYMER CHEMISTRY 8.35(2017):5275-5285. |
入库方式： OAI收割
来源：上海药物研究所
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