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Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer

文献类型：期刊论文

作者Zhang, Meng1,3; Liu, Ergang3,4; Cui, Yanna2,3; Huang, Yongzhuo1,3
刊名CANCER BIOLOGY & MEDICINE
出版日期2017-08
卷号14期号:3页码:212-227
ISSN号2095-3941
DOI10.20892/j.issn.2095-3941.2017.0054
文献子类Review
英文摘要Multidrug resistance (MDR) is a major obstacle to successful cancer treatment and is crucial to cancer metastasis and relapse. Combination therapy is an effective strategy for overcoming MDR. However, the different pharmacokinetic (PK) profiles of combined drugs often undermine the combination effect in vivo, especially when greatly different physicochemical properties (e.g., those of macromolecules and small drugs) combine. To address this issue, nanotechnology-based codelivery techniques have been actively explored. They possess great advantages for tumor targeting, controlled drug release, and identical drug PK profiles. Thus, a powerful tool for combination therapy is provided, and the translation from in vitro to in vivo is facilitated. In this review, we present a summary of various combination strategies for overcoming MDR and the nanotechnology-based combination therapy.
WOS关键词CHEMO-PHOTOTHERMAL THERAPY ; DRUG-DELIVERY SYSTEM ; TARGETED CO-DELIVERY ; GLYCOPROTEIN MEDIATED EFFLUX ; BREAST-CANCER ; P-GLYCOPROTEIN ; IN-VITRO ; SILICA NANOPARTICLES ; OVARIAN-CANCER ; SURVIVORSHIP STATISTICS
资助项目National Basic Research Program of China[973 Program 2014CB931900] ; National Basic Research Program of China[2013CB932503] ; National Natural Science Foundation of China[81373357] ; National Natural Science Foundation of China[81422048] ; National Natural Science Foundation of China[81673382] ; National Natural Science Foundation of China[81521005]
WOS研究方向Oncology ; Research & Experimental Medicine
语种英语
CSCD记录号CSCD:6066839
WOS记录号WOS:000417395100002
出版者CHINESE ANTI-CANCER ASSOC
源URL[http://119.78.100.183/handle/2S10ELR8/272534]  
专题药物制剂研究中心
通讯作者Huang, Yongzhuo
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
2.Chinese Acad Sci, Inst Neurosci, Key Lab Primate Neurobiol, Shanghai 200031, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
4.Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China;
推荐引用方式
GB/T 7714		 Zhang, Meng,Liu, Ergang,Cui, Yanna,et al. Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer[J]. CANCER BIOLOGY & MEDICINE,2017,14(3):212-227.
APA Zhang, Meng,Liu, Ergang,Cui, Yanna,&Huang, Yongzhuo.(2017).Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer.CANCER BIOLOGY & MEDICINE,14(3),212-227.
MLA Zhang, Meng,et al."Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer".CANCER BIOLOGY & MEDICINE 14.3(2017):212-227.

入库方式： OAI收割

来源：上海药物研究所

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