Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography
文献类型：期刊论文
| 作者 | Wu, Li3; Wang, Manli2,3; Singh, Vikramjeet3; Li, Haiyan3 ; Guo, Zhen1,3; Gui, Shuangying2; York, Peter1; Xiao, Tiqiao4; Yin, Xianzhen1,3; Zhang, Jiwen2,3
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| 刊名 | ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
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| 出版日期 | 2017-07 |
| 卷号 | 12期号:4页码:326-334 |
| 关键词 | Three dimensional Synchrotron radiation X-ray microcomputed tomography Distribution Microsphere Sucrose stearate |
| ISSN号 | 1818-0876 |
| DOI | 10.1016/j.ajps.2017.02.001 |
| 文献子类 | Article |
| 英文摘要 | This study investigated the formulation mechanism of microspheres via internal surfactant distribution. Eudragit L100 based microspheres loaded with bovine serum albumin were prepared by solid in oil in oil emulsion solvent evaporation method using acetone and liquid paraffin system containing sucrose stearate as a surfactant. The fabricated microspheres were evaluated for encapsulation efficiency, particle size, production yield, and in vitro release characteristics. The internal structures of microspheres were characterized using synchrotron radiation X-ray microcomputed tomography (SR-mu CT). The enhanced contrast made the sucrose stearate distinguished from Eudragit to have its three dimensional (3D) distribution. Results indicated that the content and concentration determined the state of sucrose stearate and had significant influences on the release kinetics of protein. The dispersity of sucrose stearate was the primary factor that controlled the structure of the microspheres and further affected the encapsulation efficiency, effective drug loading, as well as in vitro release behavior. In conclusion, the 3D internal distribution of surfactant in microspheres and its effects on protein release behaviors have been revealed for the first time. The highly resolved 3D architecture provides new evidence for the deep understanding of the microsphere formation mechanism. (C) 2017 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. |
| WOS关键词 | MICROPARTICLE FORMATION ; SOLVENT EVAPORATION ; PLGA MICROSPHERES ; RELEASE BEHAVIOR ; DRUG-RELEASE ; MECHANISM ; MICROENCAPSULATION ; ENCAPSULATION ; STABILITY ; SINGLE |
| 资助项目 | National Natural Science Foundation of China[81430087] ; National Science and Technology Major Project[2013ZX09402103] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000412473800002 |
| 出版者 | HONG KONG ASIAMED PUBLISH HOUSE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272574]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang, Jiwen |
| 作者单位 | 1.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England; 2.Anhui Univ Chinese Med, Sch Pharmaceut Sci, Hefei 230038, Anhui, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China; 4.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Li,Wang, Manli,Singh, Vikramjeet,et al. Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography[J]. ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,2017,12(4):326-334. |
| APA | Wu, Li.,Wang, Manli.,Singh, Vikramjeet.,Li, Haiyan.,Guo, Zhen.,...&Zhang, Jiwen.(2017).Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography.ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,12(4),326-334. |
| MLA | Wu, Li,et al."Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography".ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 12.4(2017):326-334. |
入库方式： OAI收割
来源：上海药物研究所
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