Hydrophobic-carbon-dot-based dual-emission micelle for ratiometric fluorescence biosensing and imaging of Cu2+ in liver cells
文献类型：期刊论文
| 作者 | Lu, Linlin2; Feng, Chongchong2; Xu, Jie2; Wang, Fengyang2; Yu, Haijun1 ; Xu, Zhiai2; Zhang, Wen2
|
| 刊名 | BIOSENSORS & BIOELECTRONICS
 |
| 出版日期 | 2017-06-15 |
| 卷号 | 92页码:101-108 |
| 关键词 | Hydrophobic carbon dots Ratiometric Micelle Fluorescence Copper ion TCPP |
| ISSN号 | 0956-5663 |
| DOI | 10.1016/j.bios.2017.01.066 |
| 文献子类 | Article |
| 英文摘要 | Copper is closely related to liver damage, therefore, it is essential to develop a simple and sensitive strategy to detect copper ions (Cu2+) in liver cells. A hydrophobic carbon dots (HCDs)-based dual-emission fluorescent probe for Cu2+ was prepared by encapsulating HCDs in micelles formed by self-assembly of amphiphilic polymer DSPE-PEG and tetrakis (4-carboxyphenyl) porphyrin (TCPP)-modified DSPE-PEG. The obtained probe showed characteristic fluorescence emissions of HCDs and TCPP with large emission shift of 170 nm with single-wavelength excitation. In the presence of Cu2+, the fluorescence of TCPP was quenched and that of HCDs remained unchanged, displaying ratiometric fluorescence response to Cu2+. The developed probe exhibited high sensitivity (detection limit down to 36 nM) and selectivity to Cu2+ over other substances, and the probe was used to image the changes of Cu2+ level in liver cells successfully. |
| WOS关键词 | ULTRASENSITIVE DETECTION ; PHOTODYNAMIC THERAPY ; GOLD NANOCLUSTERS ; LIVING CELLS ; COPPER IONS ; PROBE ; CHEMODOSIMETER ; NANOPARTICLES ; SENSOR |
| 资助项目 | National Natural Science Foundation of China[21675055] ; National Natural Science Foundation of China[21305047] ; National Natural Science Foundation of China[21375040] |
| WOS研究方向 | Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000396946600016 |
| 出版者 | ELSEVIER ADVANCED TECHNOLOGY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272608]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Xu, Zhiai |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 2.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Lu, Linlin,Feng, Chongchong,Xu, Jie,et al. Hydrophobic-carbon-dot-based dual-emission micelle for ratiometric fluorescence biosensing and imaging of Cu2+ in liver cells[J]. BIOSENSORS & BIOELECTRONICS,2017,92:101-108. |
| APA | Lu, Linlin.,Feng, Chongchong.,Xu, Jie.,Wang, Fengyang.,Yu, Haijun.,...&Zhang, Wen.(2017).Hydrophobic-carbon-dot-based dual-emission micelle for ratiometric fluorescence biosensing and imaging of Cu2+ in liver cells.BIOSENSORS & BIOELECTRONICS,92,101-108. |
| MLA | Lu, Linlin,et al."Hydrophobic-carbon-dot-based dual-emission micelle for ratiometric fluorescence biosensing and imaging of Cu2+ in liver cells".BIOSENSORS & BIOELECTRONICS 92(2017):101-108. |
入库方式： OAI收割
来源：上海药物研究所
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