Composite CD-MOF nanocrystals-containing microspheres for sustained drug delivery
文献类型：期刊论文
| 作者 | Li, Haiyan1,2 ; Lv, Nana1,3; Li, Xue1,4; Liu, Botao1,5; Feng, Jing1; Ren, Xiaohong1; Guo, Tao1; Chen, Dawei3; Stoddart, J. Fraser2; Gref, Ruxandra4
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| 刊名 | NANOSCALE
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| 出版日期 | 2017-06-14 |
| 卷号 | 9期号:22页码:7454-7463 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c6nr07593b |
| 文献子类 | Article |
| 英文摘要 | Metal-organic frameworks (MOFs), which are typically embedded in polymer matrices as composites, are emerging as a new class of carriers for sustained drug delivery. Most of the MOFs and the polymers used so far in these composites, however, are not pharmaceutically acceptable. In the investigation reported herein, composites of gamma-cyclodextrin (gamma-CD)-based MOFs (CD-MOFs) and polyacrylic acid (PAA) were prepared by a solid in oil-in-oil (s/o/o) emulsifying solvent evaporation method. A modified hydrothermal protocol has been established which produces efficiently at 50 degrees C in 6 h micron (5-10 mu m) and nanometer (500-700 nm) diameter CD-MOF particles of uniform size with smooth surfaces and powder X-ray diffraction patterns that are identical with those reported in the literature. Ibuprofen (IBU) and Lansoprazole (LPZ), both insoluble in water and lacking in stability, were entrapped with high drug loading in nanometer-sized CD-MOFs by co-crystallisation (that is more effective than impregnation) without causing MOF crystal degradation during the loading process. On account of the good dispersion of drugloaded CD-MOF nanocrystals inside polyacrylic acid (PAA) matrices and the homogeneous distribution of the drug molecules within these crystals, the composite microspheres exhibit not only spherical shapes and sustained drug release over a prolonged period of time, but they also demonstrate reduced cell toxicity. The cumulative release rate for IBU (and LPZ) follows the trend: IBU-gamma-CD complex microspheres (ca. 80% in 2 h) > IBU microspheres > IBU-CD-MOF/PAA composite microspheres (ca. 50% in 24 h). Importantly, no burst release of IBU (and LPZ) was observed from the CD-MOF/PAA composite microspheres, suggesting an even distribution of the drug as well as strong drug carrier interactions inside the CD-MOF. In summary, these composite microspheres, composed of CD-MOF nanocrystals embedded in a biocompatible polymer (PAA) matrix, constitute an efficient and pharmaceutically acceptable MOFbased carrier for sustained drug release. |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; MESOPOROUS SILICA NANOPARTICLES ; MIXED-MATRIX MEMBRANES ; ANTICANCER DRUG ; CONTROLLED-RELEASE ; CARBON-DIOXIDE ; BIOMEDICAL APPLICATIONS ; HYDROGEN STORAGE ; ENCAPSULATION ; SYSTEMS |
| 资助项目 | Natural Science Foundation of China[81373358] ; Natural Science Foundation of China[81430087] ; Natural Science Foundation of China[81573392] ; China scholarship council (CSC)[201408330166] ; Marie Curie FP7-PEOPLE-ITN "Cyclon Hit" grant[608407] ; French National Agency of Research[ANR-14-CE08-0017] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000402881600012 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272610]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Stoddart, J. Fraser; Gref, Ruxandra; Zhang, Jiwen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA; 3.Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Peoples R China; 4.Univ Paris Saclay, Univ Paris Sud, UMR CNRS 8214, Inst Sci Mol Orsay ISMO, F-91400 Orsay, France; 5.Shanghai Inst Technol, Sch Chem & Environm Engn, 500 Haiquan Rd, Shanghai 201418, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Haiyan,Lv, Nana,Li, Xue,et al. Composite CD-MOF nanocrystals-containing microspheres for sustained drug delivery[J]. NANOSCALE,2017,9(22):7454-7463. |
| APA | Li, Haiyan.,Lv, Nana.,Li, Xue.,Liu, Botao.,Feng, Jing.,...&Zhang, Jiwen.(2017).Composite CD-MOF nanocrystals-containing microspheres for sustained drug delivery.NANOSCALE,9(22),7454-7463. |
| MLA | Li, Haiyan,et al."Composite CD-MOF nanocrystals-containing microspheres for sustained drug delivery".NANOSCALE 9.22(2017):7454-7463. |
入库方式： OAI收割
来源：上海药物研究所
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