中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 药物制剂研究中心
Host-guest kinetic interactions between HP-beta-cyclodextrin and drugs for prediction of bitter taste masking

文献类型：期刊论文

作者Guo, Zhen1,3; Wu, Fei2; Singh, Vikramjeet1; Guo, Tao1; Ren, Xiaohong1; Yin, Xianzhen1,3; Shao, Qun3; York, Peter3; Patterson, Laurence H.3; Zhang, Jiwen1
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
出版日期2017-06-05
卷号140页码:232-238
关键词Cyclodextrin Kinetic parameters Taste masking Surface plasmon resonance imaging Modeling Prediction
ISSN号0731-7085
DOI10.1016/j.jpba.2017.03.042
文献子类Article
英文摘要Cyclodextrins (CD) are widely used bitter taste masking agents, for which the binding equilibrium constant (K) for the drug-CD complex is a conventional parameter for quantitating the taste masking effects. However, some exceptions have been reported to the expected relationship between K and bitterness reduction and the relationship between kinetic parameters of a drug-CD interaction, including association rate constant (K-a) and disassociation rate constant (K-d), and taste masking remains unexplored. In this study, based upon a database of kinetic parameters of drugs-HP-beta-CD generated by Surface Plasmon Resonance Imaging for 485 drugs, the host-guest kinetic interactions between drugs and HP-beta-CD for prediction of taste masking effects have been investigated. The taste masking effects of HP-beta-CD for 13 bitter drugs were quantitatively determined using an electronic gustatory system (alpha-Astree e-Tongue). Statistical software was used to establish a model based on Euclidean distance measurements, K-a and K-d of the bitter drugs/HP-beta-CD-complexes (R-2 = 0.96 and P < 0.05). Optimized parameters, K-a(3), K-d, K-a, k(d) K-d(3), K-a(2) and K-a/K-d with notable influence, were obtained by stepwise regression from 12 parameters derived from K-a, K-d and K (K-a/K-d). 10-fold cross-validation was used to verify the reliability of the model (correlation coefficient of 0.84, P < 0.05). The established model indicated a relationship between K-a, K-d, K and taste masking by HP-beta-CD and was successful in predicting the extent of taste masking by HP-beta-CD of 44 bitter drugs, which was in accordance with the literature reported. In conclusion, the relationship between kinetics of drug-CD interactions and taste masking was established and providing a new strategy for predicting the cyclodextrin mediated bitter taste masking. (C) 2017 Elsevier B.V. All rights reserved.
WOS关键词FLUORESCENCE CORRELATION SPECTROSCOPY ; BIOLOGICAL-MEMBRANES ; ELECTRONIC TONGUE ; FORMULATION ; COMPLEXES ; MECHANISMS ; DYNAMICS ; CHILDREN ; BROMIDE ; FOODS
资助项目National Natural Science Foundation of China[81430087] ; National Natural Science Foundation of China[81573392] ; National Science and Technology Major Project[2013ZX09402103]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000402850500028
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/272619]  
专题药物制剂研究中心
通讯作者Patterson, Laurence H.; Zhang, Jiwen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China;
2.Shanghai Univ Tradit Chinese Med, Engn Res Ctr Modern Preparat Technol Tradit Chine, Minist Educ, Shanghai 201203, Peoples R China
3.Univ Bradford, Sch Med Sci, Bradford BD7 1DP, W Yorkshire, England;
推荐引用方式
GB/T 7714		 Guo, Zhen,Wu, Fei,Singh, Vikramjeet,et al. Host-guest kinetic interactions between HP-beta-cyclodextrin and drugs for prediction of bitter taste masking[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2017,140:232-238.
APA Guo, Zhen.,Wu, Fei.,Singh, Vikramjeet.,Guo, Tao.,Ren, Xiaohong.,...&Zhang, Jiwen.(2017).Host-guest kinetic interactions between HP-beta-cyclodextrin and drugs for prediction of bitter taste masking.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,140,232-238.
MLA Guo, Zhen,et al."Host-guest kinetic interactions between HP-beta-cyclodextrin and drugs for prediction of bitter taste masking".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 140(2017):232-238.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。