Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the aerosolization performance for dry powder inhalation
文献类型：期刊论文
| 作者 | Peng, Tingting2; Zhang, Xuejuan2; Huang, Ying2; Zhao, Ziyu2; Liao, Qiuying2; Xu, Jing2; Huang, Zhengwei2; Zhang, Jiwen3 ; Wu, Chuan-yu1; Pan, Xin2,4
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017-05-02 |
| 卷号 | 7 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep46517 |
| 文献子类 | Article |
| 英文摘要 | An optimum carrier rugosity is essential to achieve a satisfying drug deposition efficiency for the carrier based dry powder inhalation (DPI). Therefore, a non-organic spray drying technique was firstly used to prepare nanoporous mannitol with small asperities to enhance the DPI aerosolization performance. Ammonium carbonate was used as a pore-forming agent since it decomposed with volatile during preparation. It was found that only the porous structure, and hence the specific surface area and carrier density were changed at different ammonium carbonate concentration. Furthermore, the carrier density was used as an indication of porosity to correlate with drug aerosolization. A good correlation between the carrier density and fine particle fraction (FPF) (r(2)=0.9579) was established, suggesting that the deposition efficiency increased with the decreased carrier density. Nanoporous mannitol with a mean pore size of about 6 nm exhibited 0.24-fold carrier density while 2.16-fold FPF value of the nonporous mannitol. The enhanced deposition efficiency was further confirmed from the pharmacokinetic studies since the nanoporous mannitol exhibited a significantly higher AUC(0-8h) value than the nonporous mannitol and commercial product Pulmicort. Therefore, surface modification by preparing nanoporous carrier through non-organic spray drying showed to be a facile approach to enhance the DPI aerosolization performance. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; INHALER FORMULATIONS ; DRIED MANNITOL ; DRUG-DELIVERY ; PARTICLE-SIZE ; LACTOSE ; MORPHOLOGY ; MICROPARTICLES ; AEROSOLISATION ; BUDESONIDE |
| 资助项目 | National Science Foundation of China[81673375] ; Sun Yat-Sen University[16ykpy23] ; Innovative Scientic Research Team Introducing Project of Zhongshan City[2015-224] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000400452100001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272673]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Pan, Xin; Wu, Chuanbin |
| 作者单位 | 1.Univ Surrey, Dept Chem & Proc Engn, Guildford GU2 7XH, Surrey, England; 2.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Zhongshan WanYuan New Drug R&D Co Ltd, Zhongshan City 528451, Peoples R China; 5.Guangdong Res Ctr Drug Delivery Syst, Guangzhou 510006, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Tingting,Zhang, Xuejuan,Huang, Ying,et al. Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the aerosolization performance for dry powder inhalation[J]. SCIENTIFIC REPORTS,2017,7. |
| APA | Peng, Tingting.,Zhang, Xuejuan.,Huang, Ying.,Zhao, Ziyu.,Liao, Qiuying.,...&Wu, Chuanbin.(2017).Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the aerosolization performance for dry powder inhalation.SCIENTIFIC REPORTS,7. |
| MLA | Peng, Tingting,et al."Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the aerosolization performance for dry powder inhalation".SCIENTIFIC REPORTS 7(2017). |
入库方式： OAI收割
来源：上海药物研究所
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