Microwave-Assisted Rapid Synthesis of gamma-Cyclodextrin Metal-Organic Frameworks for Size Control and Efficient Drug Loading
文献类型：期刊论文
| 作者 | Liu, Botao1,2; He, Yaping1,3; Han, Liping1; Singh, Vikramjeet1; Xu, Xiaonan1; Guo, Tao1; Meng, Fanyue1; Xu, Xu2; York, Peter1; Liu, Zhaoxin2 |
| 刊名 | CRYSTAL GROWTH & DESIGN
 |
| 出版日期 | 2017-04 |
| 卷号 | 17期号:4页码:1654-1660 |
| ISSN号 | 1528-7483 |
| DOI | 10.1021/acs.cgd.6b01658 |
| 文献子类 | Article |
| 英文摘要 | The micron and nanometer-sized gamma-cyclodextrin metal organic frameworks (gamma-CD-MOFs) were successfully synthesized using the microwave technique for the first time for rapid and facile synthesis. Polyethylene glycol 20000 (PEG 20000) was used as surfactant to control the size and morphology of gamma-CD-MOFs. The as-synthesized gamma-CD-MOFs were characterized using various techniques, including X-ray powder diffraction (PXRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and N-2 adsorption. The increment in, the reaction time and MeOH ratio dramatically damaged the crystalline integrity of gamma-CD-MOFs. Fenbufen was selected as a Model drug to evaluate the loading characteristics of gamma-CD-MOF crystals. As a result, the nanometer sized gamma-CD-MOFs (100-300 nm) showed rapid and higher adsorption (196 mg g(-1)) of Fenbufen in EtOH when compared with the micron crystals. The adsorption parameters fitted well to a pseudo-second order kinetic model and chemisorption of Fenbufen was further supported by molecular docking illustrations. In summary, the controlled synthesis of gamma-CD-MOFs was successfully achieved by microwave assisted method and resultant crystals were further evaluated for potential drug delivery applications. |
| WOS关键词 | SELECTIVE ADSORPTION ; CRYSTAL SIZE ; MORPHOLOGY ; STABILITY ; DESIGN ; MOF |
| 资助项目 | Natural Science Foundation of China[81373358] ; Natural Science Foundation of China[81430087] ; National Science and Technology Major Project[2013ZX09402103] |
| WOS研究方向 | Chemistry ; Crystallography ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000398884400028 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272719]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Liu, Zhaoxin; Zhang, Jiwen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China; 2.Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Botao,He, Yaping,Han, Liping,et al. Microwave-Assisted Rapid Synthesis of gamma-Cyclodextrin Metal-Organic Frameworks for Size Control and Efficient Drug Loading[J]. CRYSTAL GROWTH & DESIGN,2017,17(4):1654-1660. |
| APA | Liu, Botao.,He, Yaping.,Han, Liping.,Singh, Vikramjeet.,Xu, Xiaonan.,...&Zhang, Jiwen.(2017).Microwave-Assisted Rapid Synthesis of gamma-Cyclodextrin Metal-Organic Frameworks for Size Control and Efficient Drug Loading.CRYSTAL GROWTH & DESIGN,17(4),1654-1660. |
| MLA | Liu, Botao,et al."Microwave-Assisted Rapid Synthesis of gamma-Cyclodextrin Metal-Organic Frameworks for Size Control and Efficient Drug Loading".CRYSTAL GROWTH & DESIGN 17.4(2017):1654-1660. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。