Evaluation of drug loading capabilities of gamma-cyclodextrin-metal organic frameworks by high performance liquid chromatography
文献类型：期刊论文
| 作者 | Xu, Xiaonan1,2; Wang, Caifen1; Li, Haiyan1 ; Li, Xue1,3; Liu, Botao1; Singh, Vikramjeet1; Wang, Shuxia1; Sun, Lixin2; Gref, Ruxandra3; Zhang, Jiwen1
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| 刊名 | JOURNAL OF CHROMATOGRAPHY A
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| 出版日期 | 2017-03-10 |
| 卷号 | 1488页码:37-44 |
| 关键词 | Metal-organic frameworks gamma-CD-MOFs Retention Drug loading efficiency |
| ISSN号 | 0021-9673 |
| DOI | 10.1016/j.chroma.2017.01.062 |
| 文献子类 | Article |
| 英文摘要 | Drug loading into gamma-cyclodextrin-metal organic frameworks (gamma-CD-MOFs) using the impregnation approach is a laborious process. In this study, a gamma-CD-MOF construct (2-5 mu m particle diameter) was used as the stationary phase under HPLC conditions with the aim to correlate retention properties and drug loading capability of the CD-based structure. Ketoprofen, fenbufen and diazepam were chosen as model drugs with m-xylene as a control analyte to investigate the correlation of drug loading and their chromatographic behaviour in the gamma-CD-MOF column. Furthermore, gamma-CD itself was also prepared as the stationary phase by coupling with silica in the column to illustrate the enhanced interaction between drugs and gamma-CD-MOF as a reference. The retention and loading efficiency of the drugs were determined with different ratios of hexane and ethanol (10:90, 20:80, 50:50, 80:20, 90:10, v/v) at temperatures of 20, 25, 30 and 37 degrees C. With the increment in hexane content, the loading efficiency of ketoprofen and fenbufen increased from 2.39 +/- 0.06% to 4.38 +/- 0.04% and from 5.82 +/- 0.94% to 6.37 +/- 0.29%, respectively. The retention time and loading efficiency of ketoprofen and diazepam were the lowest at 30 degrees C while those of fenbufen had the different tendency. The excellent relation between the retention and loading efficiency onto gamma-CD-MOF could be clearly observed through mobile phase and temperature investigation. In conclusion, a highly efficient chromatographic method has been established to evaluate the drug loading capability of gamma-CD-MOF. (C) 2017 Elsevier B.V. All rights reserved |
| WOS关键词 | HUMAN SERUM-ALBUMIN ; AFFINITY-CHROMATOGRAPHY ; PROTEIN DISSOCIATION ; STATIONARY-PHASE ; SEPARATION ; DELIVERY ; MOF |
| 资助项目 | National Natural Science Foundation of China[81573392] ; National Natural Science Foundation of China[81430087] ; National Natural Science Foundation of China[81373358] ; National Science and Technology Major Project[2013ZX09402103] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000395853700005 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272743]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Sun, Lixin; Gref, Ruxandra; Zhang, Jiwen |
| 作者单位 | 1.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut Anal, Shenyang 110016, Peoples R China; 3.Univ Paris Saclay, CNRS, Inst Sci Mol Orsay, UMR 8214, F-91400 Orsay, France |
| 推荐引用方式 GB/T 7714 | Xu, Xiaonan,Wang, Caifen,Li, Haiyan,et al. Evaluation of drug loading capabilities of gamma-cyclodextrin-metal organic frameworks by high performance liquid chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2017,1488:37-44. |
| APA | Xu, Xiaonan.,Wang, Caifen.,Li, Haiyan.,Li, Xue.,Liu, Botao.,...&Zhang, Jiwen.(2017).Evaluation of drug loading capabilities of gamma-cyclodextrin-metal organic frameworks by high performance liquid chromatography.JOURNAL OF CHROMATOGRAPHY A,1488,37-44. |
| MLA | Xu, Xiaonan,et al."Evaluation of drug loading capabilities of gamma-cyclodextrin-metal organic frameworks by high performance liquid chromatography".JOURNAL OF CHROMATOGRAPHY A 1488(2017):37-44. |
入库方式： OAI收割
来源：上海药物研究所
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