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PEGylated nanostructured lipid carriers loaded with 10-hydroxycamptothecin: an efficient carrier with enhanced anti-tumour effects against lung cancer

文献类型：期刊论文

作者Zhang, Xinxin1,2; Gan, Yong1; Gan, Li1; Nie, Shufang2; Pan, Weisan2
刊名JOURNAL OF PHARMACY AND PHARMACOLOGY
出版日期2008-08
卷号60期号:8页码:1077-1087
ISSN号0022-3573
DOI10.1211/jpp.60.8.0014
文献子类Article
英文摘要Most drugs do not have the pharmacokinetic features required for optimal pulmonary delivery. In this study, we developed PEGylated nanostructured lipid carriers (PEG-NLCs) to improve the delivery of anti-tumour agents to lung tumours. PEG-40 NLCs modified with PEG-40 stearate (molecular weight 2000 Da), PEG-100 NLCs modified with PEG-100 stearate (molecular weight 5000 Da) and NLCs without PEG modification were prepared by melt-emulsification and homogenization, and were loaded with 10-hydroxycamptothecin (HCPT). They were investigated in terms of physiological characteristics, biodistribution, cellular uptake, and anti-tumour effect in-vivo. PEG-NLCs exhibited regular morphology, with a spherical shape. The particle size (measured by laser diffraction) was approximately 100 nm. Encapsulation in PEG-NLCs protected the active lactone form of HCPT compared with HCPT solution after incubation with plasma. In biodistribution studies, PEG-NLCs, especially PEG-40 NLCs, had longer circulation time and decreased uptake by the reticuloenclothelial system (RES) compared with unmodified NLCs. PEG-NLCs accumulated in the lungs after i.v. injection in mice. PEG-NLCs showed enhanced cellular uptake by human lung adenocarcinoma epithelial A549 cells. In-vivo experiments indicated that PEG-NLCs loaded with HCPT have superior efficacy against A549 lung cancer compared with HCPT solution and NLCs. These results suggest that PEG-NLCs is a promising delivery system for HCPT in the treatment of lung cancer.
WOS关键词POLYETHYLENEGLYCOL-COATED LIPOSOMES ; PROTEIN SURFACE INTERACTIONS ; VASCULAR-PERMEABILITY ; NANOPARTICLES ; SYSTEM ; TUMOR ; SIZE ; DELIVERY ; CELLS ; OXIDE
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000257834800014
出版者WILEY-BLACKWELL
源URL[http://119.78.100.183/handle/2S10ELR8/272858]  
专题药物制剂研究中心
通讯作者Pan, Weisan
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China;
推荐引用方式
GB/T 7714		 Zhang, Xinxin,Gan, Yong,Gan, Li,et al. PEGylated nanostructured lipid carriers loaded with 10-hydroxycamptothecin: an efficient carrier with enhanced anti-tumour effects against lung cancer[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY,2008,60(8):1077-1087.
APA Zhang, Xinxin,Gan, Yong,Gan, Li,Nie, Shufang,&Pan, Weisan.(2008).PEGylated nanostructured lipid carriers loaded with 10-hydroxycamptothecin: an efficient carrier with enhanced anti-tumour effects against lung cancer.JOURNAL OF PHARMACY AND PHARMACOLOGY,60(8),1077-1087.
MLA Zhang, Xinxin,et al."PEGylated nanostructured lipid carriers loaded with 10-hydroxycamptothecin: an efficient carrier with enhanced anti-tumour effects against lung cancer".JOURNAL OF PHARMACY AND PHARMACOLOGY 60.8(2008):1077-1087.

入库方式： OAI收割

来源：上海药物研究所

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