Optimization and evaluation of time-dependent tablets comprising an immediate and sustained release profile using artificial neural network
文献类型：期刊论文
| 作者 | Xie, Huijun1,3; Gan, Yong1,3 ; Ma, Suwei1,3; Gan, Li1; Chen, Qinghua2
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| 刊名 | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
 |
| 出版日期 | 2008-04 |
| 卷号 | 34期号:4页码:363-372 |
| 关键词 | artificial neural network response surface method time-dependent tablets isosorbide-5-mononitrate |
| ISSN号 | 0363-9045 |
| DOI | 10.1080/03639040701657701 |
| 文献子类 | Article |
| 英文摘要 | The aim of this work was to optimize time-dependent tablets using artificial neural network (ANN). The time-dependent tablet consisted of a tablet core, which contained sustained release pellets (70% isosorbide-5-mononitrate [5-ISMN]), immediate release granules (30% 5-ISMN), superdisintegrating agent (sodium carboxymethylstarch, CMS-Na), and other excipients, surrounded by a coating layer composed of a water-insoluble ethylcellulose and a water-soluble channeling agent. The chosen independent variables, i.e., X, coating level of tablets, X-1 coating level of pellets, and X-3 CMS-Na level, were optimized with a three-factor, threelevel Box-Behnken design. Data were analyzed for modeling and optimizing the release profile using ANN. Response surface plots were used to relate the dependent and the independent variables. The optimized values for the factors X-1-X-3 were 4.1, 14.1, and 29.8%, respectively. Optimized formulations were prepared according to the factor combinations dictated by ANN. In each case, the observed drug release data of the optimized formulations were close to the predicted release pattern. An in vitro model for predicting the effect of food on release behavior of optimized products was used in this study. It was concluded that neural network technique could be particularly suitable in the pharmaceutical technology of time-dependent dosage forms where systems were complex and nonlinear relationships often existed between the independent and the dependent variables. |
| WOS关键词 | DISSOLUTION ; FORMULATIONS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000255341600003 |
| 出版者 | TAYLOR & FRANCIS INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272947]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gan, Yong |
| 作者单位 | 1.Chinese Acad Sci, Inst Mat Medica, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; 2.Shanghai Inst Pharmaceut Ind, Shanghai, Peoples R China 3.Shanghai Pharmaceut Grp Co Ltd, Cent Res Inst, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xie, Huijun,Gan, Yong,Ma, Suwei,et al. Optimization and evaluation of time-dependent tablets comprising an immediate and sustained release profile using artificial neural network[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2008,34(4):363-372. |
| APA | Xie, Huijun,Gan, Yong,Ma, Suwei,Gan, Li,&Chen, Qinghua.(2008).Optimization and evaluation of time-dependent tablets comprising an immediate and sustained release profile using artificial neural network.DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,34(4),363-372. |
| MLA | Xie, Huijun,et al."Optimization and evaluation of time-dependent tablets comprising an immediate and sustained release profile using artificial neural network".DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 34.4(2008):363-372. |
入库方式： OAI收割
来源：上海药物研究所
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