Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: Pharmacokinetics and anti-tumor effects
文献类型：期刊论文
| 作者 | Li, YP ; Pei, YY; Zhou, ZH; Zhang, XY; Gu, ZH; Ding, J; Zhou, JJ; Gao, XJ; Zhu, JH
|
| 刊名 | BIOLOGICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2001-06 |
| 卷号 | 24期号:6页码:662-665 |
| 关键词 | poly(ethylene glycol) poly(alkyl cyanoacrylate) nanoparticle stealth poly(methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate) turner necrosis factor-alpha |
| ISSN号 | 0918-6158 |
| DOI | 10.1248/bpb.24.662 |
| 文献子类 | Article |
| 英文摘要 | The objective of this study was to investigate the pharmacokinetics and in vivo anti-tumor effect of recombinant human tumor necrosis factor-a (rHuTNF-alpha) encapsulated in poly(methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate) (PEG-PHDCA) nanoparticles, Our experimental results showed that PEG-PHDCA nanoparticles could extend the half-life of rHuTNF-alpha to 7.42 h and obviously change the protein biodistribution in tissues, and in particular, increase accumulation of rHuTNF-alpha in tumor. Compared with PHDCA nanoparticles and free rHuTNF-alpha PEG-PHDCA nanoparticles loaded with rHuTNF-alpha showed higher antitumor potency at the same dose, which might be related to its higher accumulation in tumor tissues and longer plasma circulation time. Therefore, PEG-PHDCA nanoparticles could be an effective carrier for rHuTNF-alpha. |
| WOS关键词 | AMPHIPHILIC COPOLYMER ; CIRCULATION TIME ; TNF-ALPHA ; NANOSPHERES ; LIPOSOMES ; SARCOMA ; RATS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000169026200013 |
| 出版者 | PHARMACEUTICAL SOC JAPAN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274487]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, YP |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, Shanghai 200031, Peoples R China 2.Fudan Univ, Dept Pharmaceut, Sch Pharm, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, YP,Pei, YY,Zhou, ZH,et al. Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: Pharmacokinetics and anti-tumor effects[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2001,24(6):662-665. |
| APA | Li, YP.,Pei, YY.,Zhou, ZH.,Zhang, XY.,Gu, ZH.,...&Zhu, JH.(2001).Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: Pharmacokinetics and anti-tumor effects.BIOLOGICAL & PHARMACEUTICAL BULLETIN,24(6),662-665. |
| MLA | Li, YP,et al."Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: Pharmacokinetics and anti-tumor effects".BIOLOGICAL & PHARMACEUTICAL BULLETIN 24.6(2001):662-665. |
入库方式： OAI收割
来源：上海药物研究所
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