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Ginkgolide A, B, and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells

文献类型：期刊论文

作者Zhao, HW; Li, XY
刊名ACTA PHARMACOLOGICA SINICA
出版日期1999-10
卷号20期号:10页码:941-943
关键词ginkgolide A ginkgolide B huperzine A nitric oxide cultured tumor cells astrocytoma
ISSN号0253-9756
文献子类Article
英文摘要AIM: To study the effects of ginkgolide A, B (Gin A, Gin B) and 'huperzine A (Hup A) on nitric oxide (NO) production from cultured astrocytes. METHODS: Nitrites in supernatants were measured with Griess assay. RESULTS: Hup A 0.001-100 mu mol.L-1 time- and concentration-dependently inhibited the NO production from rat C6 astrocytoma cells. The NO production from C6 cells was concentration-dependently inhibited by the treatment with Gin A or Gin B 0.001-10 mu mol.L-1 for 24 h. The NO production from human BT325 astrocytoma cells was concentration-dependently inhibited by Hup A, Gin A, or Gin B 0.01 -10 mu mol.L-1 for 24 h. CONCLUSION: Gin A, Gin B, and Hup A inhibited astrocytes producing NO.
WOS关键词CYTOKINES ; NEUROTOXICITY
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000083036100015
出版者ACTA PHARMACOLOGICA SINICA
源URL[http://119.78.100.183/handle/2S10ELR8/274685]  
专题药物制剂研究中心
通讯作者Li, XY
作者单位Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, HW,Li, XY. Ginkgolide A, B, and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells[J]. ACTA PHARMACOLOGICA SINICA,1999,20(10):941-943.
APA Zhao, HW,&Li, XY.(1999).Ginkgolide A, B, and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells.ACTA PHARMACOLOGICA SINICA,20(10),941-943.
MLA Zhao, HW,et al."Ginkgolide A, B, and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells".ACTA PHARMACOLOGICA SINICA 20.10(1999):941-943.

入库方式： OAI收割

来源：上海药物研究所

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