Effects of ginkgolides on interleukin-1, tumor necrosis factor-alpha and nitric oxide production by rat microglia stimulated with lipopolysaccharides in vitro
文献类型：期刊论文
| 作者 | Du, ZE; Li, XY |
| 刊名 | ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
 |
| 出版日期 | 1998-12 |
| 卷号 | 48期号:12页码:1126-1130 |
| 关键词 | apafant BN52020 BN52021 CAS 15291-75-5 CAS 15291-77-7 CAS 105219-56-5 ginkgolide A ginkgolide B microglia, production of proinflammatory cytokines and NO |
| ISSN号 | 0004-4172 |
| 文献子类 | Article |
| 英文摘要 | The effects of ginkgolide A (CAS 15291-75-5, BN52020, GA) and B (CAS 15291-77-7, BN52021, GB) on interleukin (IL)-1, tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) production in resting and lipopolysaccharide (LPS)-stimulated cultured neonatal rat microglia were studied. Apafant (CAS 105219-56-5), a platelet activating factor (PAF) antagonist of triazolobenzodiazepine type was used as control. The biological activities of IL-1 and TNF-alpha were tested by mouse thymocyte proliferation and L929 cytotoxicity assay, respectively. NO concentration was represented by nitrite and determined by Griess reaction. GA 1 nmol/l-10 mu mol/l inhibited IL-1 production. and 100 nmol/l - 10 mu mol/l decreased TNF-alpha and NO production in dose-dependent manner. GB inhibited IL-1, TNF-alpha and NO production at the concentrations 10 nmol/l-10 mu mol/l, 100 nmol/l-10 mu mol/l and 10 nmol/l-10 mu mol/l, respectively. Apafant inhibited IL-1, but not TNF-alpha and NO production GB plus apafant (50 mu mol/l) showed IL-1 and NO inhibitory effects, but not on TNF-alpha. The manner was different from that of GB or apafant alone. The results suggested that GA and GB inhibited proinflammatory cytokines and NO production from LPS-stimulated rat microglia. however, apafant inhibited IL-1 production only. The effects of GA and GB on proinflammatory cytokines and NO production from rat microglia do not seem to be based on PAF receptor antagonism. In addition. GA and GB are regarded as promising agents for the treatment of some neurodegenerative diseases in the central nervous system. |
| WOS关键词 | BILOBA EXTRACT EGB-761 ; AUTOIMMUNE ENCEPHALOMYELITIS ; MULTIPLE-SCLEROSIS ; DOUBLE-BLIND ; CELL ; BRAIN ; ANTAGONISTS ; INVITRO ; OLIGODENDROCYTES ; MACROPHAGES |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000077745600002 |
| 出版者 | ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274783]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, XY |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, ZE,Li, XY. Effects of ginkgolides on interleukin-1, tumor necrosis factor-alpha and nitric oxide production by rat microglia stimulated with lipopolysaccharides in vitro[J]. ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH,1998,48(12):1126-1130. |
| APA | Du, ZE,&Li, XY.(1998).Effects of ginkgolides on interleukin-1, tumor necrosis factor-alpha and nitric oxide production by rat microglia stimulated with lipopolysaccharides in vitro.ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH,48(12),1126-1130. |
| MLA | Du, ZE,et al."Effects of ginkgolides on interleukin-1, tumor necrosis factor-alpha and nitric oxide production by rat microglia stimulated with lipopolysaccharides in vitro".ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 48.12(1998):1126-1130. |
入库方式： OAI收割
来源：上海药物研究所
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