Comparison of (-)-stepholidine and D-1 or D-2 agonists on unit firing of globus pallidus in 6-hydroxydopamine-lesioned rats
文献类型：期刊论文
| 作者 | Zhang, XX ; Zhu, ZT; Jin, GZ
|
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 1998-07-10 |
| 卷号 | 63期号:7页码:537-544 |
| 关键词 | (-)-stepholidine dopamine receptor agonists 6-hydroxydopamine globus pallidus unit firing |
| ISSN号 | 0024-3205 |
| DOI | 10.1016/S0024-3205(98)00304-X |
| 文献子类 | Article |
| 英文摘要 | (-)-Stepholidine(SPD), isolated from the Chinese herb Stephania, is demonstrated to be a DA antagonist, but it also shows D-1 agonistic action on rotational behavior in unilateral 6-hydroxydopamine (6-OHDA) lesioned rats. The present study further ascertains its D-1 agonistic property on firing activity of globus pallidus (GP) in control and 6-OHDA-lesioned rats. In the control rats, the firing activities of the GP neurons elicited by DA agonists (i.v.), such as apomorphine (D-1/D-2), SKF38393 (D-1), and LY171555 (D-2), were readily reversed by SPD (4 mg/kg, i.v.); but SPD, per se, induced variable alterations. In the 6-OHDA-lesioned rats, apomorphine, SKF38393 and LY171555 displayed the marked inhibition as well as excitation on the unit firing. The individual firing variations (87.1+/-17.8, 55.1+/-15.7 and 62.1+/-16.7%, respectively) were much larger than those in the control group, and were completely abolished by SPD (2 mg/kg). However, SPD also showed D-1 partial agonistic action on the GP neuron firing. Moreover, the pre-blockade of D-2 receptors with spiperone (0.5 mg/kg, i.v.), SPD exhibited the D-1 agonist action which was reversed by the D-1 antagonist SCH23390. These results suggest that SPD has a dual action on the GP neuron firing in the 6-OHDA-lesioned rats, i.e., antagonist to D-2 DA receptors and partial agonist to D-1 receptors. |
| WOS关键词 | BASAL GANGLIA ; DOPAMINE ; NEURONS |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000074957300003 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274817]  |
| 专题 | 院士及顾问专家 药物制剂研究中心 |
| 通讯作者 | Jin, GZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, XX,Zhu, ZT,Jin, GZ. Comparison of (-)-stepholidine and D-1 or D-2 agonists on unit firing of globus pallidus in 6-hydroxydopamine-lesioned rats[J]. LIFE SCIENCES,1998,63(7):537-544. |
| APA | Zhang, XX,Zhu, ZT,&Jin, GZ.(1998).Comparison of (-)-stepholidine and D-1 or D-2 agonists on unit firing of globus pallidus in 6-hydroxydopamine-lesioned rats.LIFE SCIENCES,63(7),537-544. |
| MLA | Zhang, XX,et al."Comparison of (-)-stepholidine and D-1 or D-2 agonists on unit firing of globus pallidus in 6-hydroxydopamine-lesioned rats".LIFE SCIENCES 63.7(1998):537-544. |
入库方式： OAI收割
来源：上海药物研究所
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