Immunomodulating effects of methionine enkephalin
文献类型：期刊论文
| 作者 | Li, XY |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1998-01 |
| 卷号 | 19期号:1页码:3-6 |
| 关键词 | neuroimmunomodulation methionine enkephalin naloxone opioid receptors interleukins lipopolysaccharides tumor necrosis factor messenger RNA gene expression |
| ISSN号 | 0253-9756 |
| 文献子类 | Review |
| 英文摘要 | Methionine enkephalin (Met-Enk), the endogenous neuropeptide, is suggested to be involved in the regulatory loop between immune and neuroendocrine systems. Our studies showed that Met-Enk over a wide range of concentrations increased interleukin-1 (IL-1) production from mouse peritoneal macrophages induced by lipopolysaccharides (LPS) and naloxone did not block the enhancing effect, Met-Enk promoted the proliferation of mouse splenocyte and the production of IL-2 and IL-6 in a dose-dependent manner. The up-regulating effects of IL-2 and IL-6 not only augmented their mRNA transcription but also increased their stability. Thus Met-Enk appears to be an important immunomodulatory signaling molecule to exert regulatory actions concerned with the expressing of pre-inflammatory cytokines. |
| WOS关键词 | 3' UNTRANSLATED REGION ; MET-ENKEPHALIN ; MESSENGER-RNA ; TRANSCRIPTION FACTOR ; GENE-EXPRESSION ; BETA-ENDORPHIN ; INTERLEUKIN-6 ; BRAIN ; CELLS ; PROLIFERATION |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000071424500001 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274865]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Li, XY |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, XY. Immunomodulating effects of methionine enkephalin[J]. ACTA PHARMACOLOGICA SINICA,1998,19(1):3-6. |
| APA | Li, XY.(1998).Immunomodulating effects of methionine enkephalin.ACTA PHARMACOLOGICA SINICA,19(1),3-6. |
| MLA | Li, XY."Immunomodulating effects of methionine enkephalin".ACTA PHARMACOLOGICA SINICA 19.1(1998):3-6. |
入库方式： OAI收割
来源：上海药物研究所
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