Atypical neuroleptic properties of l-stepholidine
文献类型：期刊论文
| 作者 | Zhang, XX ; Sun, BC; Jin, GZ
|
| 刊名 | SCIENCE IN CHINA SERIES C-LIFE SCIENCES
 |
| 出版日期 | 1997-10 |
| 卷号 | 40期号:5页码:531-538 |
| 关键词 | stepholidine atypical neuroleptics dopaminergic neuron depolarization inactivation catalepsy |
| ISSN号 | 1006-9305 |
| DOI | 10.1007/BF03183593 |
| 文献子类 | Article |
| 英文摘要 | Intravenous administration of l-stepholidine (SPD), a dopamine (DA) receptor antagonist, increased the firing rate of DA neurons located in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNC) in both anaesthetized and paralyzed rats. However, with the increase of dose, SPD selectively inhibited the firing activity of DA neurons in the VTA but not in the SNC. The inhibition was reversed by the DA agonist apomorphine (APO), suggesting that it may be via the mechanism of depolarization inactivation (DI). In rats, chronic administration of SPD for 21 d dose-dependently decreased the number of spontaneously active DA neurons in the VTA, of which effect was reversed by APO (i.v.). In contrast, the same treatment failed to affect the population of DA neurons in the SNC. Similarly, the acute treatment of SPD also decreased the number of spontaneously firing DA neurons in the VTA, but not in the SNC. SPD per se only induced very weak catalepsy. Its catalepsy which was not in proportion to dosage was only observed in the dose range of 10-40 mg/kg and lasted 15 min. SPD effectively antagonized the APO (2 mg/kg, i.p.)-induced stereotypy. The above-mentioned results suggest that SPD selectively inactivates the DA neurons in the VTA not in the SNC. SPD may associate with a low incidence of extrapyramidal side-effects and may be ranked as a promising compound for searching for a new kind of atypical neuroleptics. |
| WOS关键词 | MIDBRAIN DOPAMINE NEURONS |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:A1997XU77200013 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274884]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL 1,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Zhang, XX,Sun, BC,Jin, GZ. Atypical neuroleptic properties of l-stepholidine[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,1997,40(5):531-538. |
| APA | Zhang, XX,Sun, BC,&Jin, GZ.(1997).Atypical neuroleptic properties of l-stepholidine.SCIENCE IN CHINA SERIES C-LIFE SCIENCES,40(5),531-538. |
| MLA | Zhang, XX,et al."Atypical neuroleptic properties of l-stepholidine".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 40.5(1997):531-538. |
入库方式： OAI收割
来源：上海药物研究所
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