Effects of tetrahydroprotoberberines on dopamine D-2 receptors in ventral tegmental area of rat
文献类型：期刊论文
| 作者 | Wang, LM; Zhang, XX ; Jin, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1997-03 |
| 卷号 | 18期号:2页码:143-146 |
| 关键词 | tetrahydroprotoberberines ventral tegmental area dopamine D-2 receptors action potentials apomorphine Sch-23390 haloperidol |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To compare the actions of tetrahydroprotoberberines (THPB) on dopa;nine (DA) D-2 receptors in the ventral tegmental area (VTA) of rat. METHODS: Extracellular single unit recording technique was used in iv gallamine-paralyzed rats. RESULTS: Eleven THPB analogs tested completely attenuated the apomorphine (Apo, 20 mu g . kg(-1))-induced inhibition on VTA DA cell firing activity. The OH group on C-2 at THPB was linked with the reversal of Apo-induced inhibition. Their reversal potencies (ED(50), mu g . L(-1)) for D-2 receptors were: THPB-143 (5.6) > SPD (8.5) > Iso (17.0) > THP (33) > THE (48) > THPB-18 (66) > THPB-1 (179) > THPB-19 (408) > THPI-126 (510) > THPB-104 (1019) > THPB-10 (4815). CONCLUSION: Among these 11 THPB, the 2-hydroxyl-THPB (THPB-143) showed the strongest antagonistic action on D-2 receptors. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:411910 |
| WOS记录号 | WOS:A1997WM32200013 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274920]  |
| 专题 | 药物制剂研究中心 院士及顾问专家 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Wang, LM,Zhang, XX,Jin, GZ. Effects of tetrahydroprotoberberines on dopamine D-2 receptors in ventral tegmental area of rat[J]. ACTA PHARMACOLOGICA SINICA,1997,18(2):143-146. |
| APA | Wang, LM,Zhang, XX,&Jin, GZ.(1997).Effects of tetrahydroprotoberberines on dopamine D-2 receptors in ventral tegmental area of rat.ACTA PHARMACOLOGICA SINICA,18(2),143-146. |
| MLA | Wang, LM,et al."Effects of tetrahydroprotoberberines on dopamine D-2 receptors in ventral tegmental area of rat".ACTA PHARMACOLOGICA SINICA 18.2(1997):143-146. |
入库方式： OAI收割
来源：上海药物研究所
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