AGONISTIC ACTIONS OF PERGOLIDE ON FIRING ACTIVITY OF DOPAMINE NEURONS IN SUBSTANTIA-NIGRA COMPACTA AREA
文献类型：期刊论文
| 作者 | ZHANG, XX ; JIN, GZ; WEI, YF
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1995-09 |
| 卷号 | 16期号:5页码:423-427 |
| 关键词 | PERGOLIDE BROMOCRIPTINE SPIPERONE SUBSTANTIA NIGRA DOPAMINE RECEPTORS ELECTROPHYSIOLOGY |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the potency of pergolide as a D-2 receptor agonist on the firing activity of substantia nigra compacta (SNC) dopamine (DA) neurons compared with that of bromocriptine and to determine whether pergolide has the nature of D-1 receptor agonist in vivo. METHODS: Extracellular single unit recording techniques. RESULTS: Both pergolide and bromocriptine decreased the spontaneously firing rate of ''sensitive'' and ''insensitive'' DA cells. In regard of ID50 values, pergolide (11.9, 95 % fiducial limits, 5.7-25.1 mu g kg(-1)) was more potent than bromocriptine (7.8, 95 % fiducial limits, 3.3 -18.5 mg kg(-1)). The discharge inhibition of pergolide was attenuated following the injection of selective D-2 receptor antagonist spiperone 0.25 mg kg(-1) or selective D-1 receptor antagonist Sch-23390 1-2 mg kg(-1). However, the inhibition caused by bromocriptine was not always attenuated by spiperone. CONCLUSION: Pergolide is 650 times more potent than bromocriptine at D-2 receptors, and possesses D-1 receptor agonist characteristics in vivo. |
| WOS关键词 | RECEPTORS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1995RU48600011 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275027]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | ZHANG, XX,JIN, GZ,WEI, YF. AGONISTIC ACTIONS OF PERGOLIDE ON FIRING ACTIVITY OF DOPAMINE NEURONS IN SUBSTANTIA-NIGRA COMPACTA AREA[J]. ACTA PHARMACOLOGICA SINICA,1995,16(5):423-427. |
| APA | ZHANG, XX,JIN, GZ,&WEI, YF.(1995).AGONISTIC ACTIONS OF PERGOLIDE ON FIRING ACTIVITY OF DOPAMINE NEURONS IN SUBSTANTIA-NIGRA COMPACTA AREA.ACTA PHARMACOLOGICA SINICA,16(5),423-427. |
| MLA | ZHANG, XX,et al."AGONISTIC ACTIONS OF PERGOLIDE ON FIRING ACTIVITY OF DOPAMINE NEURONS IN SUBSTANTIA-NIGRA COMPACTA AREA".ACTA PHARMACOLOGICA SINICA 16.5(1995):423-427. |
入库方式： OAI收割
来源：上海药物研究所
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