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IMMUNOMODULATING EFFECTS OF MORPHINE MICROINJECTED INTO PERIAQUEDUCTAL GRAY

文献类型：期刊论文

作者BIAN, TH; LI, XY
刊名ACTA PHARMACOLOGICA SINICA
出版日期1995-03
卷号16期号:2页码:121-124
关键词MORPHINE NALOXONE PERIAQUEDUCTAL GRAY T-LYMPHOCYTES MACROPHAGES NATURAL KILLER CELLS
ISSN号0253-9756
文献子类Article
英文摘要AIM: To study the effects of morphine on immune system through rat brain periaqueductal gray (PAG). METHODS: Three hours after microinjection of morphine through the implanted steel tubes to PAG, splenic cytokines interleukin 2 (IL-2), interleukin 6 (IL-6), a tumor necrosis factor (TNF), and natural killer cells (NK) activity were measured. RESULTS: Microinjection of morphine (0.5 mu L, 3672 ng) into PAG region had no influence on IL-6 and TNF-alpha (production of splenic macrophages, suppressed the natural killer cell (NK) activity and enhanced T-lymphocyte functions, including concanavalin A (Con A)-induced T-cell proliferation, IL-2 and TNF-beta production. Both the suppressive and stimulating actions were blocked by PAG preinjection of the mu opioid receptor antagonist naloxone (0.5 mu L, 1 mu g), which alone showed the contrary effect to morphine. CONCLUSION: Morphine affected immunofunctions through opioid receptors in PAG, and the influences on various immunocompetent calls were different.
WOS关键词TUMOR NECROSIS FACTOR ; STRESS
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:A1995QM01800006
出版者ACTA PHARMACOLOGICA SINICA
源URL[http://119.78.100.183/handle/2S10ELR8/275058]  
专题药物制剂研究中心
作者单位CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA
推荐引用方式
GB/T 7714		 BIAN, TH,LI, XY. IMMUNOMODULATING EFFECTS OF MORPHINE MICROINJECTED INTO PERIAQUEDUCTAL GRAY[J]. ACTA PHARMACOLOGICA SINICA,1995,16(2):121-124.
APA BIAN, TH,&LI, XY.(1995).IMMUNOMODULATING EFFECTS OF MORPHINE MICROINJECTED INTO PERIAQUEDUCTAL GRAY.ACTA PHARMACOLOGICA SINICA,16(2),121-124.
MLA BIAN, TH,et al."IMMUNOMODULATING EFFECTS OF MORPHINE MICROINJECTED INTO PERIAQUEDUCTAL GRAY".ACTA PHARMACOLOGICA SINICA 16.2(1995):121-124.

入库方式： OAI收割

来源：上海药物研究所

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