INFLUENCE OF METHIONINE-ENKEPHALIN ON INTERLEUKIN-2 PRODUCTION AND INTERLEUKIN-2 RECEPTOR EXPRESSION
文献类型：期刊论文
| 作者 | YANG, SX; LI, XY |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1992-03 |
| 卷号 | 13期号:2页码:131-136 |
| 关键词 | METHIONINE ENKEPHALIN INTERLEUKIN-2 INTERLEUKIN-2 RECEPTORS DELAYED HYPERSENSITIVITY LYMPHOCYTE TRANSFORMATION |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Influences of methionine enkephalin (met-enk) on delayed hypersensitivity (DH) against 2,4-dinitrofluoro-benzene (DNFB) and interleukin-2 (IL-2) production of mouse lymphocytes were examined. Met-enk enhanced the DH response to ear challenge when mice were treated with met-enk beginning at the same time as epicutaneous sensitization with DNFB but not after being sensitized. When met-enk (10 nmol.L-1-100-mu-mol.L-1) was included in Con A-stimulated lymphocyte cultures, the IL-2 production increased in a concentration-dependent manner. Furthermore, in vivo treatment with met-enk also increased IL-2 production of splenocytes, and the enhancement of IL-2 production was parallel to that of lymphocyte proliferation. However, met-enk 10 nmol.L-1 had no effect on IL-2 receptor expression on thymocytes, splenocytes, and gut-associated lymphocytes. The data suggested that the stimulative effect of met-enk on lymphocytes may be mediated through the increase of IL-2, but not through the IL-2 receptor expression. |
| WOS关键词 | BETA-ENDORPHIN ; IL-2 PRODUCTION ; CELLS ; ENHANCEMENT ; PROLIFERATION |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1992HH11200009 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275170]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | YANG, SX,LI, XY. INFLUENCE OF METHIONINE-ENKEPHALIN ON INTERLEUKIN-2 PRODUCTION AND INTERLEUKIN-2 RECEPTOR EXPRESSION[J]. ACTA PHARMACOLOGICA SINICA,1992,13(2):131-136. |
| APA | YANG, SX,&LI, XY.(1992).INFLUENCE OF METHIONINE-ENKEPHALIN ON INTERLEUKIN-2 PRODUCTION AND INTERLEUKIN-2 RECEPTOR EXPRESSION.ACTA PHARMACOLOGICA SINICA,13(2),131-136. |
| MLA | YANG, SX,et al."INFLUENCE OF METHIONINE-ENKEPHALIN ON INTERLEUKIN-2 PRODUCTION AND INTERLEUKIN-2 RECEPTOR EXPRESSION".ACTA PHARMACOLOGICA SINICA 13.2(1992):131-136. |
入库方式： OAI收割
来源：上海药物研究所
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