Improvement in Thermal Stability of Sucralose by Y-Cyclodextrin Metal-Organic Frameworks
文献类型：期刊论文
| 作者 | Lv, Nana1,2; Guo, Tao2; Liu, Botao2,3; Wang, Caifen2; Singh, Vikaramjeet2; Xu, Xiaonan1,2; Li, Xue1,4; Chen, Dawei1; Gref, Ruxandra4; Zhang, Jiwen1,2
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| 刊名 | PHARMACEUTICAL RESEARCH
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| 出版日期 | 2017-02 |
| 卷号 | 34期号:2页码:269-278 |
| 关键词 | cyclodextrin metal-organic frameworks sucralose thermal stability |
| ISSN号 | 0724-8741 |
| DOI | 10.1007/s11095-016-059-1 |
| 文献子类 | Article |
| 英文摘要 | Purpose To explain thermal stability enhancement of an organic compound, sucralose, with cyclodextrin based metal organic frameworks. Methods Micron and nanometer sized basic CD-MOFs were successfully synthesized by a modified vapor diffusion method and further neutralized with glacial acetic acid. Sucralose was loaded into CD-MOFs by incubating CDMOFs with sucralose ethanol solutions. Thermal stabilities of sucralose-loaded basic CD-MOFs and neutralized CDMOFs were investigated using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and high performance liquid chromatography with evaporative lightscattering detection (HPLC-ELSD). Results Scanning electron microscopy (SEM) and powder Xray diffraction (PXRD) results showed that basic CD-MOFs were cubic crystals with smooth surface and uniform sizes. The basic CD-MOFs maintained their crystalline structure after neutralization. HPLC-ELSD analysis indicated that the CD-MOF crystal size had significant influence on sucralose loading (SL). The maximal SL of micron CD-MOFs (CDMOF-Micro) was 17.5 +/- 0.9% (w/w). In contrast, 27.9 +/- 1.4% of sucralose could be loaded in nanometer-sized basic CD-MOFs (CD-MOF-Nano). Molecular docking modeling showed that sucralose molecules preferentially located inside the cavities of gamma-CDs pairs in CD-MOFs. Raw sucralose decomposed fast at 90(o)C, with 86.2 +/- 0.2% of the compound degraded within only 1 h. Remarkably, sucralose stability was dramatically improved after loading in neutralized CDMOFs, with only 13.7 +/- 0.7% degradation at 90(o)C within 24 h. Conclusions CD-MOFs efficiently incorporated sucralose and maintained its integrity upon heating at elevated temperatures. |
| WOS关键词 | ARTIFICIAL SWEETENER SUCRALOSE ; DRUG-DELIVERY ; CARBON-DIOXIDE ; ENCAPSULATION ; CURCUMIN ; ACID |
| 资助项目 | National Natural Science Foundation of China[81430087] ; National Science and Technology Major Project[2013ZX09402103] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000396060200003 |
| 出版者 | SPRINGER/PLENUM PUBLISHERS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275643]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Chen, Dawei; Gref, Ruxandra; Zhang, Jiwen |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 2.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201210, Peoples R China; 3.Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China; 4.Univ Paris Saclay, Univ Paris Sud, UMR CNRS 8214, Inst Mol Sci Orsay, F-91400 Orsay, France |
| 推荐引用方式 GB/T 7714 | Lv, Nana,Guo, Tao,Liu, Botao,et al. Improvement in Thermal Stability of Sucralose by Y-Cyclodextrin Metal-Organic Frameworks[J]. PHARMACEUTICAL RESEARCH,2017,34(2):269-278. |
| APA | Lv, Nana.,Guo, Tao.,Liu, Botao.,Wang, Caifen.,Singh, Vikaramjeet.,...&Zhang, Jiwen.(2017).Improvement in Thermal Stability of Sucralose by Y-Cyclodextrin Metal-Organic Frameworks.PHARMACEUTICAL RESEARCH,34(2),269-278. |
| MLA | Lv, Nana,et al."Improvement in Thermal Stability of Sucralose by Y-Cyclodextrin Metal-Organic Frameworks".PHARMACEUTICAL RESEARCH 34.2(2017):269-278. |
入库方式： OAI收割
来源：上海药物研究所
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