Ordered and disordered cyclodextrin nanosponges with diverse physicochemical properties
文献类型：期刊论文
| 作者 | Singh, Vikramjeet1,4; Xu, Jianghui4; Wu, Li4; Liu, Botao4; Guo, Tao4; Guo, Zhen3,4; York, Peter3,4; Gref, Ruxandra2; Zhang, Jiwen4
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:38页码:23759-23764 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c7ra00584a |
| 文献子类 | Article |
| 英文摘要 | Herein, in addition to conventional beta-CD-NSPs, the NSPs of alpha, gamma, HP-beta, methyl-beta, and SBE-beta cyclodextrins were synthesized by a simple modified approach and thoroughly characterized. The control of CDs derivatization over structural dimensions and properties was clearly observed. It is interesting to note the complete transformation of beta-CD from its crystalline form to its non-crystalline derivatives and the further reversal when the derivatives are prepared into NSPs including those of a and gamma-CDs (as observed by PXRD). The SEM images revealed the different morphologies and porous structure of NSPs and, in particular, the NSPs of methyl-beta-CD exhibited regular spherical shapes. Two drugs of different categories, doxorubicin and captopril, were evaluated for loading efficiencies, which were found to significantly vary with cross-linker ratio (1 : 4 and 1 : 6) and CD types. Together, all the synthesized NSPs provide a new horizon to try to solve existing problems relating to drug delivery. |
| WOS关键词 | DRUG-DELIVERY SYSTEMS ; BETA-CYCLODEXTRIN ; SPECTROSCOPY ; CAPTOPRIL ; TOXICITY ; POLYMER |
| 资助项目 | National Natural Science Foundation of China[81430087] ; National Science and Technology Major Project[2013ZX09402103] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000400874700059 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275720]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | York, Peter; Gref, Ruxandra; Zhang, Jiwen |
| 作者单位 | 1.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China 2.Univ Paris Saclay, Inst Mol Sci Orsay, Univ Paris Sud, UMR CNRS 8214, F-91400 Orsay, France; 3.Univ Bradford, Bradford BD7 1DP, W Yorkshire, England; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Singh, Vikramjeet,Xu, Jianghui,Wu, Li,et al. Ordered and disordered cyclodextrin nanosponges with diverse physicochemical properties[J]. RSC ADVANCES,2017,7(38):23759-23764. |
| APA | Singh, Vikramjeet.,Xu, Jianghui.,Wu, Li.,Liu, Botao.,Guo, Tao.,...&Zhang, Jiwen.(2017).Ordered and disordered cyclodextrin nanosponges with diverse physicochemical properties.RSC ADVANCES,7(38),23759-23764. |
| MLA | Singh, Vikramjeet,et al."Ordered and disordered cyclodextrin nanosponges with diverse physicochemical properties".RSC ADVANCES 7.38(2017):23759-23764. |
入库方式： OAI收割
来源：上海药物研究所
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