Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload
文献类型：期刊论文
| 作者 | Singh, Vikramjeet2,3; Guo, Tao2; Wu, Li2; Xu, Jianghui2; Liu, Botao2; Gref, Ruxandra1; Zhang, Jiwen2
|
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:34页码:20789-20794 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c7ra02306e |
| 文献子类 | Article |
| 英文摘要 | Despite its 3D porous structure, the pharmaceutical applications of cyclodextrin based cross-linked polymers are limited due to their structural irregularities. To address this issue, a template-directed strategy is used to obtain cubic micro and nano cyclodextrin cross-linked polymer (CD-cubes) from cyclodextrin metal organic frameworks in this study. The well-organized gamma-CDs in MOFs were crosslinked by diphenyl carbonate by a facile single step chemical reaction. Scanning electron microscopy and X-ray diffraction analysis revealed the almost perfect cubic shapes of the particles with a disordered internal structure. Contrarily to the non-crosslinked materials which immediately dissolved in water, the CD-cubes were remarkably stable after extensive washing with water. The CD-cubes possessed a mesoporous structure with pore size in the range of 2-4 nm and showed much higher BET surface and 8 times higher adsorption capacity for doxorubicin as compared to conventional cyclodextrin-sponges. |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; NANOSPONGES ; SPECTROSCOPY ; STABILITY ; DELIVERY |
| 资助项目 | National Natural Science Foundation of China[81430087] ; [ANR-14-CE08-0017] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000399722300011 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275723]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gref, Ruxandra; Zhang, Jiwen |
| 作者单位 | 1.Univ Paris Sud, UMR CNRS 8214, Univ Paris Saclay, Inst Sci Mol Orsay, F-91400 Orsay, France; 2.Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China; 3.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Singh, Vikramjeet,Guo, Tao,Wu, Li,et al. Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload[J]. RSC ADVANCES,2017,7(34):20789-20794. |
| APA | Singh, Vikramjeet.,Guo, Tao.,Wu, Li.,Xu, Jianghui.,Liu, Botao.,...&Zhang, Jiwen.(2017).Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload.RSC ADVANCES,7(34),20789-20794. |
| MLA | Singh, Vikramjeet,et al."Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload".RSC ADVANCES 7.34(2017):20789-20794. |
入库方式： OAI收割
来源：上海药物研究所
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