Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Liang, Jinying1,2,3; Zhang, Xinxin1 ; Miao, Yunqiu1; Li, Juan2; Gan, Yong1
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| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
 |
| 出版日期 | 2017 |
| 卷号 | 12 |
| 关键词 | dual-imaging magnetic resonance imaging hepatocellular carcinoma tumor-targeting |
| ISSN号 | 1178-2013 |
| DOI | 10.2147/IJN.S128525 |
| 文献子类 | Article |
| 英文摘要 | The development of noninvasive imaging techniques for the accurate diagnosis of progressive hepatocellular carcinoma (HCC) is of great clinical significance and has always been desired. Herein, a hepatocellular carcinoma cell-targeting fluorescent magnetic nanoparticle (NP) was obtained by conjugating near-infrared fluorescence to the surface of Fe3O4 (NIRF-Fe3O4) NPs, followed by coating the lipids consisting of tumoral hepatocytes-targeting polymer (GalP123). This magnetic NP (GPC@NIRF-Fe3O4) with superparamagnetic behavior showed high stability and safety in physiological conditions. In addition, GPC@NIRF-Fe3O4 achieved more specific uptake of human liver cancer cells than free Fe3O4 NPs. Importantly, with superparamagnetic iron oxide and strong NIR absorbance, GPC@NIRF-Fe3O4 NPs demonstrate prominent tumor-contrasted imaging performance both on fluorescent and T-2-weighted magnetic resonance (MR) imaging modalities in a living body. The relative MR signal enhancement of GPC@NIRFFe3O4 NPs achieved 5.4-fold improvement compared with NIR-Fe3O4 NPs. Therefore, GPC@ NIRF-Fe3O4 NPs may be potentially used as a candidate for dual-modal imaging of tumors with information covalidated and directly compared by combining fluorescence and MR imaging. |
| WOS关键词 | MAGNETIC-RESONANCE ; FE3O4 NANOPARTICLES ; PHOTOTHERMAL THERAPY ; IN-VIVO ; ASIALOGLYCOPROTEIN RECEPTOR ; CONTRAST AGENTS ; TUMOR ; MR ; CELLS ; NANOCOMPOSITES |
| 资助项目 | National Natural Science Foundation of China[81571796] ; Youth Innovation Promotion Association[2015229] ; SA-SIBS Scholarship Program[00000000] |
| WOS研究方向 | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000396152200001 |
| 出版者 | DOVE MEDICAL PRESS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275730]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang, Xinxin; Li, Juan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.China Pharmaceut Univ, Dept Pharmaceut, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China; 3.Xinxiang Med Univ, Sch Pharm, Xinxiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Jinying,Zhang, Xinxin,Miao, Yunqiu,et al. Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12. |
| APA | Liang, Jinying,Zhang, Xinxin,Miao, Yunqiu,Li, Juan,&Gan, Yong.(2017).Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma.INTERNATIONAL JOURNAL OF NANOMEDICINE,12. |
| MLA | Liang, Jinying,et al."Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma".INTERNATIONAL JOURNAL OF NANOMEDICINE 12(2017). |
入库方式： OAI收割
来源：上海药物研究所
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