Spontaneous Self-Assembly of Polymeric Nanoparticles in Aqueous Media: New Insights From Microfluidics, In Situ Size Measurements, and Individual Particle Tracking
文献类型：期刊论文
| 作者 | Li, Xue1,2; Salzano, Giuseppina2; Zhang, Jiwen1 ; Gref, Ruxandra2
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| 刊名 | JOURNAL OF PHARMACEUTICAL SCIENCES
 |
| 出版日期 | 2017-01 |
| 卷号 | 106期号:1页码:395-401 |
| 关键词 | cyclodextrins nanoparticles particle size distribution self-assembly |
| ISSN号 | 0022-3549 |
| DOI | 10.1016/j.xphs.2016.09.024 |
| 文献子类 | Article |
| 英文摘要 | Supramolecular cyclodextrin-based nanoparticles (CD-NPs) mediated by host-guest interactions have gained increased popularity because of their "green" and simple preparation procedure, as well as their versatility in terms of inclusion of active molecules. Herein, we showed that original CD-NPs of around 100 nm are spontaneously formed in water, by mixing 2 aqueous solutions of (1) a CD polymer and (2) dextran grafted with benzophenone moieties. For the first time, CD-NPs were instantaneously produced in a microfluidic interaction chamber by mixing 2 aqueous solutions of neutral polymers, in the absence of organic solvents. Whatever the mixing conditions, CD-NPs with narrow size distributions were immediately formed upon contact of the 2 polymeric solutions. In situ size measurements showed that the CD-NPs were spontaneously formed. Nanoparticle tracking analysis was used to individually follow the CD-NPs in their Brownian motions, to gain insights on their size distribution, concentration, and stability on extreme dilution. Nanoparticle tracking analysis allowed to establish that despite their non-covalent nature, and the CD-NPs were remarkably stable in terms of concentration and size distribution, even on extreme dilution (concentrations as low as 100 ng/mL). (C) 2016 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved. |
| WOS关键词 | BETA-CYCLODEXTRIN ; NANOGELS ; DRUG ; NANOASSEMBLIES ; PLATFORM |
| 资助项目 | China scholarship council (CSC)[201408330166] ; China National Science and Technology Major Project[2013ZX09402103] ; National Natural Science Foundation[81430087] ; French ANR[ANR-14-CE08-0017] ; European Marie Curie project "Cyclon Hit" FP7-PEOPLE-ITN[608407] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000393920500043 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275732]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang, Jiwen; Gref, Ruxandra |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China 2.Univ Paris 11, Univ Paris Saclay, Inst Sci Mol Orsay, UMR CNRS 8214, F-91400 Orsay, France; |
| 推荐引用方式 GB/T 7714 | Li, Xue,Salzano, Giuseppina,Zhang, Jiwen,et al. Spontaneous Self-Assembly of Polymeric Nanoparticles in Aqueous Media: New Insights From Microfluidics, In Situ Size Measurements, and Individual Particle Tracking[J]. JOURNAL OF PHARMACEUTICAL SCIENCES,2017,106(1):395-401. |
| APA | Li, Xue,Salzano, Giuseppina,Zhang, Jiwen,&Gref, Ruxandra.(2017).Spontaneous Self-Assembly of Polymeric Nanoparticles in Aqueous Media: New Insights From Microfluidics, In Situ Size Measurements, and Individual Particle Tracking.JOURNAL OF PHARMACEUTICAL SCIENCES,106(1),395-401. |
| MLA | Li, Xue,et al."Spontaneous Self-Assembly of Polymeric Nanoparticles in Aqueous Media: New Insights From Microfluidics, In Situ Size Measurements, and Individual Particle Tracking".JOURNAL OF PHARMACEUTICAL SCIENCES 106.1(2017):395-401. |
入库方式： OAI收割
来源：上海药物研究所
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