Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy
文献类型：期刊论文
| 作者 | Cui, Yanna2,3; Zhang, Meng2; Zeng, Feng1,2,4; Jin, Hongyue2; Xu, Qin1; Huang, Yongzhuo2
|
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2016-11-30 |
| 卷号 | 8期号:47页码:32159-32169 |
| ISSN号 | 1944-8244 |
| 关键词 | brain targeting delivery magnetic targeting PLGA nanoparticles paclitaxel curcumin T7 peptide |
| DOI | 10.1021/acsami.6b10175 |
| 文献子类 | Article |
| 英文摘要 | Chemotherapy is one of the most important strategies for glioma treatment. However, the "impermeability" of the blood brain barrier (BBB) impedes most chemotherapeutics from entering the brain, thereby rendering very few drugs suitable for glioma therapy, letting alone application of a combination of chemotherapeutics. Thereby, there is a pressing need to overcome the obstacles. A dual-targeting strategy was developed by a combination of magnetic guidance and transferrin receptor-binding peptide T7-mediated active targeting delivery. The T7-modified magnetic PLGA nano particle (NP) system was prepared with co-encapsulation of the hydrophobic magnetic nanoparticles and a combination of drugs (i.e., paclitaxel and curcumin) based on a "one-pot" process. The combined drugs yielded synergistic effects on inhibition of tumor growth via the mechanisms of apoptosis induction and cell cycle arrest, displaying significantly increased efficacy relative to the single use of each drug. Dual-targeting effects yielded a >10-fold increase in cellular uptake studies and a >5-fold enhancement in brain delivery compared to the nontargeting NPs. For the in vivo studies with an orthotopic glioma model, efficient brain accumulation was observed by using fluorescence imaging, synchrotron radiation X-ray imaging, and MM. Furthermore, the antiglioma treatment efficacy of the delivery system was evaluated. With application of a magnetic field, this system exhibited enhanced treatment efficiency and reduced adverse effects. All mice bearing orthotopic glioma survived, compared to a 62.5% survival rate for the combination group receiving free drugs. This dual-targeting, co-delivery strategy provides a potential method for improving brain drug delivery and antiglioma treatment efficacy. |
| WOS关键词 | IRON-OXIDE NANOPARTICLES ; TRANSFERRIN RECEPTOR ; DRUG-DELIVERY ; CANCER-CELLS ; DOXORUBICIN ; BARRIER ; TRANSPORT ; SYSTEMS ; ARREST ; MRI |
| 资助项目 | 973 Program, China[2013CB932503] ; 973 Program, China[2014CB931900] ; NFSC[81373357] ; NFSC[81402885] ; NFSC[81422048] ; NFSC[81673382] ; China's Postdoctoral Science Foundation[133646] ; China's Postdoctoral Science Foundation[2014M551475] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000389161600009 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275791]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | 1.Guangzhou Univ Chinese Med, Inst Trop Med, 12 Jichang Rd, Guangzhou 501405, Guangdong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Key Lab Primate Neurobiol, Inst Neurosci, Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 4.Fudan Univ, Sch Pharm, Minist Educ, Key Lab Smart Drug Delivery, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cui, Yanna,Zhang, Meng,Zeng, Feng,et al. Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(47):32159-32169. |
| APA | Cui, Yanna,Zhang, Meng,Zeng, Feng,Jin, Hongyue,Xu, Qin,&Huang, Yongzhuo.(2016).Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy.ACS APPLIED MATERIALS & INTERFACES,8(47),32159-32169. |
| MLA | Cui, Yanna,et al."Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy".ACS APPLIED MATERIALS & INTERFACES 8.47(2016):32159-32169. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。