Optimized synthesis and crystalline stability of gamma-cyclodextrin metal-organic frameworks for drug adsorption
文献类型：期刊论文
| 作者 | Liu, Botao2,3; Li, Haiyan1,2 ; Xu, Xiaonan2; Li, Xue2,4; Lv, Nana2; Singh, Vikramjeet2; Stoddart, J. Fraser1; York, Peter2; Xu, Xu3; Gref, Ruxandra4
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| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
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| 出版日期 | 2016-11-30 |
| 卷号 | 514期号:1页码:212-219 |
| 关键词 | Cyclodextrin-metal-organic frameworks Synthesis Crystalline stability Drug adsorption |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2016.09.029 |
| 文献子类 | Article |
| 英文摘要 | The biocompatible and renewable cyclodextrin metal-organic frameworks (CD-MOFs) have addressed a range of opportunities in molecular storage and separation sciences. The reported protocols for their synthesis, however, were carried out at room temperature over long time periods of time (24 h), producing crystals of relatively poor uniformity. In this investigation, micron sized gamma-CD-MOFs were synthesized by an optimized vapor diffusion method at elevated temperature (50 degrees C) within 6 h, after which the size control, crystalline stability and drug adsorption behavior were investigated in detail. In this manner, uniform cubic gamma-CD-MOF crystals were obtained when the reaction temperature was raised to 50 degrees C with pre-addition of the reaction solvent. The size of gamma-CD-MOFs was adjusted efficiently by changing the reactant concentrations, temperatures, time, gamma-CD ratios to KOH and surfactant concentrations, without influencing the porosity and crystallinity of the material markedly. Varing degrees of reduction in crystallinity and change in morphology were observed when the gamma-CD-MOF crystals are treated under conditions of high temperature (100 degrees C), high humidity (92.5%) and polar solvents (e.g., MeOH and DMF). In relation to drug adsorption by gamma-CD-MOFs, most of the drug molecules containing carboxyl groups showed relatively high adsorption (> 5%), while low adsorption (< 5%) was found for drugs with nitrogen-containing heterocyclic rings. In addition, the adsorption kinetics of captopril to standard gamma-CD-MOFs matched a pseudo-second-order model rather well, whilst captopril adsorption to the damaged gamma-CD-MOFs only partially matched the pseudo-second-order model. In summary, based upon the optimized synthesis and size control of gamma-CD-MOFs, the crystalline stability and drug adsorption characteristics of gamma-CD-MOF crystals have been evaluated as a fundamental requirement of a potential vehicle for drug delivery. (C) 2016 Elsevier B.V. All rights reserved. |
| WOS关键词 | MOLECULAR RECOGNITION ; MOF ; SIZE ; MORPHOLOGY ; LIGANDS ; GROWTH ; SITES ; ACID |
| 资助项目 | National Science and Technology Major Project[2013ZX09402103] ; National Natural Science Foundation of China[81373358] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000387778200027 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275792]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Xu, Xu; Gref, Ruxandra; Zhang, Jiwen |
| 作者单位 | 1.Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China; 4.Univ Paris Saclay, Inst Sci Mol Orsay, Univ Paris Sud, UMR CNRS 8214, F-91405 Orsay, France |
| 推荐引用方式 GB/T 7714 | Liu, Botao,Li, Haiyan,Xu, Xiaonan,et al. Optimized synthesis and crystalline stability of gamma-cyclodextrin metal-organic frameworks for drug adsorption[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2016,514(1):212-219. |
| APA | Liu, Botao.,Li, Haiyan.,Xu, Xiaonan.,Li, Xue.,Lv, Nana.,...&Zhang, Jiwen.(2016).Optimized synthesis and crystalline stability of gamma-cyclodextrin metal-organic frameworks for drug adsorption.INTERNATIONAL JOURNAL OF PHARMACEUTICS,514(1),212-219. |
| MLA | Liu, Botao,et al."Optimized synthesis and crystalline stability of gamma-cyclodextrin metal-organic frameworks for drug adsorption".INTERNATIONAL JOURNAL OF PHARMACEUTICS 514.1(2016):212-219. |
入库方式： OAI收割
来源：上海药物研究所
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