Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues
文献类型：期刊论文
| 作者 | Yu, Miaorong1,2; Wang, Jiuling1,3,4; Yang, Yiwei1,2; Zhu, Chunliu2 ; Su, Qian1,3,4; Guo, Shiyan2; Sun, Jiashu1,3; Gan, Yong1,2; Shi, Xinghua1,3,4; Gao, Huajian5
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| 刊名 | NANO LETTERS
 |
| 出版日期 | 2016-11 |
| 卷号 | 16期号:11页码:7176-7182 |
| 关键词 | Mucus penetration nanoparticle diffusion shape dependent molecular simulations transmucosal delivery |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.6b03515 |
| 文献子类 | Article |
| 英文摘要 | Mucus is a viscoelastic gel layer that typically protects exposed surfaces of the gastrointestinal (GI) tract, lung airways, and other mucosal tissues. Particles targeted to these tissues can be efficiently trapped and removed by mucus, thereby limiting the effectiveness of such drug delivery systems. In this study, we experimentally and theoretically demonstrated that cylindrical nanoparticles. (NPs), such as mesoporous silica nanorods and calcium phosphate nanorods, have superior transport and trafficking capability in mucus compared with spheres of the same chemistry. The higher diffusivity of nanorods leads to deeper mucus penetration and a longer retention time in the GI tract than that of their spherical counterparts. Molecular simulations and stimulated emission of depletion (STED) microscopy revealed that this anomalous phenomenon can be attributed to the rotational dynamics of the NPs facilitated by the mucin fibers and the shear flow. These findings shed new light on the shape design of NP-based drug delivery systems targeted to mucosal and tumor sites that possess a fibrous structure/porous medium. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; DRUG-DELIVERY ; GASTROINTESTINAL MUCUS ; POLYMERIC NANOPARTICLES ; PARTICLE-TRANSPORT ; MAMMALIAN-CELLS ; SHAPE ; DIFFUSION ; SIZE ; MACROMOLECULES |
| 资助项目 | National Natural Science Foundation of China[81373356] ; National Natural Science Foundation of China[81573378] ; National Natural Science Foundation of China[11422215] ; National Natural Science Foundation of China[11272327] ; National Natural Science Foundation of China[11672079] ; "Science and technology innovation action plan for basic research" of Shanghai[14JC1493200] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120153020] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000387625000067 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275837]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gan, Yong; Shi, Xinghua; Gao, Huajian |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Nanosyst & Hierarchy Fabricat, Ctr Excellence Nanosci, Beijing 100190, Peoples R China; 4.Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China; 5.Brown Univ, Sch Engn, Providence, RI 02912 USA |
| 推荐引用方式 GB/T 7714 | Yu, Miaorong,Wang, Jiuling,Yang, Yiwei,et al. Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues[J]. NANO LETTERS,2016,16(11):7176-7182. |
| APA | Yu, Miaorong.,Wang, Jiuling.,Yang, Yiwei.,Zhu, Chunliu.,Su, Qian.,...&Gao, Huajian.(2016).Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues.NANO LETTERS,16(11),7176-7182. |
| MLA | Yu, Miaorong,et al."Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues".NANO LETTERS 16.11(2016):7176-7182. |
入库方式： OAI收割
来源：上海药物研究所
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