Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer
文献类型：期刊论文
| 作者 | Wang, Fengyang3; Sun, Qianqian3; Feng, Bing1; Xu, Zhiai3; Zhang, Junying3; Xu, Jie3; Lu, Linlin3; Yu, Haijun1 ; Wang, Mingwei2; Li, Yaping1
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| 刊名 | ADVANCED HEALTHCARE MATERIALS
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| 出版日期 | 2016-09-07 |
| 卷号 | 5期号:17页码:2227-2236 |
| 关键词 | chemotherapy dopamine gold nanostar graphene oxide photothermal therapy |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.201600283 |
| 文献子类 | Article |
| 英文摘要 | Breast cancer is the leading cancer type diagnosed in the female population, and cancer metastasis is the main reason for cancer-caused mortality. A novel nanoplatform is herein presented integrating polydopamine-functionalized nanosized reduced graphene oxide (NRGO), gold nanostars (GNS), and doxorubicin (DOX) (denoted as NRGO-GNS@DOX) for combinational treatment of metastatic breast cancer. Upon localized near infrared (NIR) laser irradiation, the NRGO-GNS@DOX nanocomposites induce significant cytotoxicity in 4T1 breast cancer cells due to a cumulative therapy effect of NRGO-GNS-elicited hyperthermia and DOX-induced cytotoxicity. Antitumor studies in orthotopic 4T1 breast tumor-bearing nude mice demonstrate that NRGO-GNS@DOX in combination with NIR laser irradiation inhibit the tumor growth and suppress the lung metastasis. Contribution of DOX-caused apoptosis of the cancer cells and hyperthermia-induced deconstruction of the tumor-associated blood vessels may account for the superior antitumor performance of the NRGO-GNS@DOX nanocomposites. These results imply a good potential of NRGO-GNS@DOX for combined photothermal and chemotherapy of the metastatic cancer. |
| WOS关键词 | IN-VIVO ; DRUG-DELIVERY ; STEM-CELLS ; THERAPY ; NANORODS ; TUMOR ; NANOPARTICLES ; GENOTOXICITY ; NANOSHEETS ; CHEMISTRY |
| 资助项目 | National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[21305047] ; National Natural Science Foundation of China[21375040] |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000383776300009 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275896]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Xu, Zhiai; Zhang, Wen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 2.Fudan Univ, Dept Nucl Med, Shanghai Canc Ctr, Shanghai 200032, Peoples R China 3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Fengyang,Sun, Qianqian,Feng, Bing,et al. Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer[J]. ADVANCED HEALTHCARE MATERIALS,2016,5(17):2227-2236. |
| APA | Wang, Fengyang.,Sun, Qianqian.,Feng, Bing.,Xu, Zhiai.,Zhang, Junying.,...&Zhang, Wen.(2016).Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer.ADVANCED HEALTHCARE MATERIALS,5(17),2227-2236. |
| MLA | Wang, Fengyang,et al."Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer".ADVANCED HEALTHCARE MATERIALS 5.17(2016):2227-2236. |
入库方式： OAI收割
来源：上海药物研究所
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