Sodium dodecyl sulfate/beta-cyclodextrin vesicles embedded in chitosan gel for insulin delivery with pH-selective release
文献类型：期刊论文
| 作者 | Li, Zhuo1,2; Li, Haiyan1 ; Wang, Caifen1; Xu, Jianghui1,3; Singh, Vikramjeet1; Chen, Dawei2; Zhang, Jiwen1,2
|
| 刊名 | ACTA PHARMACEUTICA SINICA B
 |
| 出版日期 | 2016-07 |
| 卷号 | 6期号:4页码:344-351 |
| 关键词 | Vesicles beta-Cyclodexl Insulin Self-assembly Gel pH-selective release |
| ISSN号 | 2211-3835 |
| DOI | 10.1016/j.apsb.2016.03.003 |
| 文献子类 | Article |
| 英文摘要 | In an answer to the challenge of enzymatic instability and low oral bioavailability of proteins/peptides, a new type of drug-delivery vesicle has been developed. The preparation, based on sodium dodecyl sulfate (SDS) and beta-cyclodextrin (beta-CD) embedded in chitosan gel, was used to successfully deliver the model drug-insulin. The self-assembled SDS/beta-CD vesicles were prepared and characterized by particle size, zeta potential, appearance, microscopic morphology and entrapment efficiency. In addition, both the interaction of insulin with vesicles and the stability of insulin loaded in vesicles in the presence of pepsin were investigated. The vesicles were crosslinkal into thermo-sensitive chitosan/beta-glycerol phosphate solution for an in-situ gel to enhance the dilution stability. The in vitro release characteristics of insulin from gels in media at different pH values were investigated. The insulin loaded vesicles chitosan hydrogel (IVG) improved the dilution stability of the vesicles and provided pH-selective sustained release compared with insulin solution chitosan hydrogel (ISG). In vitro, IVG exhibited slow release in acidic solution and relatively quick release in neutral solutions to provide drug efficacy. In simulated digestive fluid, IVG showed better sustained release and insulin protection properties compared with ISG. Thus IVG might improve the stability of insulin during its transport in vivo and contribute to the bioavailability and therapeutic effect of insulin. (C) 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. |
| WOS关键词 | PHARMACEUTICAL APPLICATIONS ; IN-VITRO ; LIPOSOMES ; NIOSOMES ; SYSTEMS ; NANOPARTICLES ; ENHANCEMENT ; CARRIERS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5751695 |
| WOS记录号 | WOS:000384896100011 |
| 出版者 | INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275963]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Chen, Dawei; Zhang, Jiwen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 3.Anhui Univ Chinese Med, Sch Pharmaceut Sci, Hefei 230038, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhuo,Li, Haiyan,Wang, Caifen,et al. Sodium dodecyl sulfate/beta-cyclodextrin vesicles embedded in chitosan gel for insulin delivery with pH-selective release[J]. ACTA PHARMACEUTICA SINICA B,2016,6(4):344-351. |
| APA | Li, Zhuo.,Li, Haiyan.,Wang, Caifen.,Xu, Jianghui.,Singh, Vikramjeet.,...&Zhang, Jiwen.(2016).Sodium dodecyl sulfate/beta-cyclodextrin vesicles embedded in chitosan gel for insulin delivery with pH-selective release.ACTA PHARMACEUTICA SINICA B,6(4),344-351. |
| MLA | Li, Zhuo,et al."Sodium dodecyl sulfate/beta-cyclodextrin vesicles embedded in chitosan gel for insulin delivery with pH-selective release".ACTA PHARMACEUTICA SINICA B 6.4(2016):344-351. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。