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Intracellular transport of nanocarriers across the intestinal epithelium

文献类型：期刊论文

作者Fan, Weiwei1; Xia, Dengning1; Zhu, Quanlei1; Hu, Lei1,2; Gan, Yong1
刊名DRUG DISCOVERY TODAY
出版日期2016-05
卷号21期号:5页码:856-863
ISSN号1359-6446
DOI10.1016/j.drudis.2016.04.007
文献子类Review
英文摘要The intestinal epithelium is the main barrier restricting the oral delivery of low-permeability drugs. Over recent years, numerous nanocarriers have been designed to improve the efficiency of oral drug delivery. However, the intracellular processes determining the transport of nanocarriers across the intestinal epithelium remain elusive, and only limited enhancement of the oral bioavailability of drugs has been achieved. Here, we review the processes involved in nanocarrier trafficking across the intestinal epithelium, including apical endocytosis, intracellular transport, and basolateral exocytosis. Understanding the complex intracellular processes of nanocarrier trafficking is particularly essential for the rational design of oral drug delivery systems.
WOS关键词ORAL-DRUG DELIVERY ; CACO-2 CELLS ; POLYMERIC NANOPARTICLES ; ANTICANCER DRUGS ; CELLULAR UPTAKE ; FUNCTIONALIZED NANOPARTICLES ; ENDOSOME MATURATION ; MODIFIED LIPOSOMES ; PROTEIN DRUGS ; IN-VITRO
资助项目National Natural Science Foundation of China[81373356] ; National Natural Science Foundation of China[81573378] ; 'Science and Technology Innovation Action Plan for Basic Research' of Shanghai[14JC1493200] ; [CASIMM0120153020]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000377229700017
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/276049]  
专题药物制剂研究中心
通讯作者Gan, Yong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
2.Univ Sci & Technol China, Nano Sci & Technol Inst, Anhua 230026, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Fan, Weiwei,Xia, Dengning,Zhu, Quanlei,et al. Intracellular transport of nanocarriers across the intestinal epithelium[J]. DRUG DISCOVERY TODAY,2016,21(5):856-863.
APA Fan, Weiwei,Xia, Dengning,Zhu, Quanlei,Hu, Lei,&Gan, Yong.(2016).Intracellular transport of nanocarriers across the intestinal epithelium.DRUG DISCOVERY TODAY,21(5),856-863.
MLA Fan, Weiwei,et al."Intracellular transport of nanocarriers across the intestinal epithelium".DRUG DISCOVERY TODAY 21.5(2016):856-863.

入库方式： OAI收割

来源：上海药物研究所

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