Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex
文献类型：期刊论文
| 作者 | Xia, Dengning1; Yu, Hongzhen1; Tao, Jinsong1,2; Zeng, Jianrong3; Zhu, Quanlei1; Zhu, Chunliu1 ; Gan, Yong1
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| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
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| 出版日期 | 2016-05-01 |
| 卷号 | 141页码:301-310 |
| 关键词 | Soluplus Sodium dodecyl sulfate Amphiphilic polymer-ionic surfactant interaction Solubilization Supersaturation |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2016.01.047 |
| 文献子类 | Article |
| 英文摘要 | Our previous study demonstrated that the retention of drug in the hydrophobic core of Soluplus micelle greatly impeded drug absorption from gastrointestinal tract. Using supersaturated polymeric micelles can improve drug release, however, insufficient maintaining of supersaturation of drug is still unfavorable for drug absorption. Here, we report adding small amount of small molecule, sodium dodecyl sulfate (SDS), to Soluplus solution can form a Soluplus-SDS complex. This complex not only showed a higher solubilization capability for the model drug cyclosporine A (CsA), but also maintained a longer period of and higher supersaturation than was achieved with Soluplus alone. The Soluplus-SDS interactions were characterized by analyzing surface tension, small-angle X-ray scattering (SAXS), fluorescence spectra, and nuclear magnetic resonance spectroscopy. The results demonstrated that the formation of Soluplus-SDS complex via SDS adsorption on hydrophobic segments of Soluplus, which have more hydrophobic domain than that of Soluplus micelle, contributed significantly to the solubilization and stabilization of supersaturated CsA. Using this amphiphilic copolymer-small molecule surfactant system, the cellular uptake and rat in vivo absorption of CsA were more effectively achieved than pure Soluplus. The area under the plasma concentration-time curve (AUC) and the maximal plasma concentration (Cmax) achieved by CsA-loaded Soluplus-SDS complex were 1.58- and 1.8-times higher than the corresponding values for CsA-loaded pure Soluplus, respectively. This study highlighted the benefits of Soluplus-SDS complex for optimizing the solubilization and oral absorption of a drug with low aqueous solubility. (C) 2016 Elsevier B.V. All rights reserved. |
| WOS关键词 | SOLID DISPERSIONS ; ADMINISTERED PACLITAXEL ; CREMOPHOR-EL ; ABSORPTION ; POLY(VINYLPYRROLIDONE) ; SURFACTANTS ; DISSOLUTION ; CELLULOSE ; PYRENE |
| 资助项目 | National Natural Science Foundation of China[81202468] ; Shanghai Science and Technology Innovation Action Plan for Basic Research[14JC1493200] |
| WOS研究方向 | Biophysics ; Chemistry ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000374197700035 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276062]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gan, Yong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd,Zhang Jiang Hi Tech Pk, Shanghai 201203, Peoples R China; 2.Nanchang Univ, Coll Med, Dept Pharm, Nanchang 330066, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, Dengning,Yu, Hongzhen,Tao, Jinsong,et al. Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2016,141:301-310. |
| APA | Xia, Dengning.,Yu, Hongzhen.,Tao, Jinsong.,Zeng, Jianrong.,Zhu, Quanlei.,...&Gan, Yong.(2016).Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex.COLLOIDS AND SURFACES B-BIOINTERFACES,141,301-310. |
| MLA | Xia, Dengning,et al."Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex".COLLOIDS AND SURFACES B-BIOINTERFACES 141(2016):301-310. |
入库方式： OAI收割
来源：上海药物研究所
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