Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy
文献类型：期刊论文
| 作者 | Wu, Meiying1; Meng, Qingshuo2; Chen, Yu1; Zhang, Lingxia1; Li, Mengli1; Cai, Xiaojun1; Li, Yaping2 ; Yu, Pengcheng2; Zhang, Linlin1; Shi, Jianlin1
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| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2016-03-09 |
| 卷号 | 28期号:10页码:1963-+ |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201505524 |
| 文献子类 | Article |
| 英文摘要 | A stability-difference-selective bond-breakage strategy for the fabrication of large-pore-sized hollow mesoporous organosilica nanoparticles (HMONs) is successfully developed. Moreover, surface-functionalized HMONs are successfully constructed to simultaneously deliver P-gp modulator siRNA and anticancer drug doxorubicin to reverse the multidrug resistance of cancer cells. |
| WOS关键词 | OVERCOMING MULTIDRUG-RESISTANCE ; SILICA NANOPARTICLES ; BIOMEDICAL APPLICATIONS ; ULTRALARGE PORES ; FACILE SYNTHESIS ; DRUG-DELIVERY ; BREAST-CANCER ; CO-DELIVERY ; RNA ; SPHERES |
| 资助项目 | National Natural Science Foundation of China[51132009] ; National Natural Science Foundation of China[51302293] ; Natural Science Foundation of Shanghai[13ZR1463500] ; Shanghai Rising-Star Program[14QA1404100] ; Shanghai Technical Platform for Testing and Characterization on Inorganic Materials[14DZ2292900] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000372308700007 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276105]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Chen, Yu; Li, Yaping; Shi, Jianlin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Ding Xi Rd, Shanghai 200050, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Meiying,Meng, Qingshuo,Chen, Yu,et al. Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy[J]. ADVANCED MATERIALS,2016,28(10):1963-+. |
| APA | Wu, Meiying.,Meng, Qingshuo.,Chen, Yu.,Zhang, Lingxia.,Li, Mengli.,...&Shi, Jianlin.(2016).Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy.ADVANCED MATERIALS,28(10),1963-+. |
| MLA | Wu, Meiying,et al."Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy".ADVANCED MATERIALS 28.10(2016):1963-+. |
入库方式： OAI收割
来源：上海药物研究所
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