中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 药物制剂研究中心
Microstructural investigation using synchrotron radiation X-ray microtomography reveals taste-masking mechanism of acetaminophen microspheres

文献类型：期刊论文

作者Guo, Zhen2,3; Yin, Xianzhen1,2; Liu, Congbiao2,4; Wu, Li2; Zhu, Weifeng4; Shao, Qun1; York, Peter1; Patterson, Laurence3; Zhang, Jiwen2,4
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
出版日期2016-02-29
卷号499期号:1-2页码:47-57
关键词Taste masking Lipid microspheres Dissolution test Microstructure Synchrotron radiation X-ray computed microtomography Three dimensional reconstruction
ISSN号0378-5173
DOI10.1016/j.ijpharm.2015.12.045
文献子类Article
英文摘要The structure of solid drug delivery systems has considerable influence on drug release behaviors from particles and granules and also impacts other properties relevant to release characteristics such as taste. In this study, lipid-based microspheres of acetaminophen were prepared to mask the undesirable taste of drug and therefore to identify the optimal formulation for drug release. Synchrotron radiation X-ray computed microtomography (SR-mu CT) was used to investigate the fine structural architectures of microspheres non-destructively at different sampling times during drug release test, which were simultaneously determined to quantitatively correlate the structural data with drug release behaviors. The results demonstrated that the polymeric formulation component, namely, cationic polymethacrylate (Eudragit E100), was the key factor to mask the bitter taste of acetaminophen by inhibiting immediate drug release thereby reducing the interaction intensity of the bitter material with the oral cavity taste buds. The structure and morphology of the microspheres were found to be influenced by the shape and particle size of the drug, which was also an important factor for taste-masking performance. The quantitative analysis generated detailed structural information which was correlated well with drug release behaviors. Thus, SR-mCT has been proved as a powerful tool to investigate the fine microstructure of particles and provides a new approach in the design of particles for taste masking. (C) 2015 Elsevier B.V. All rights reserved.
WOS关键词ORALLY DISINTEGRATING TABLETS ; CONTROLLED-RELEASE KINETICS ; OSMOTIC PUMP TABLETS ; BITTER TASTE ; COMPLEXATION APPROACH ; SOLUBLE DRUG ; FORMULATION ; GRANULES ; PELLETS ; IBUPROFEN
资助项目Chinese Academy of Sciences Visiting Professorship for Senior International Scientists[00000000] ; National Natural Science Foundation of China[81273453] ; National Natural Science Foundation of China[81430087] ; National Natural Science Foundation of China[81573615]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000370048300006
出版者ELSEVIER SCIENCE BV
源URL[http://119.78.100.183/handle/2S10ELR8/276133]  
专题药物制剂研究中心
通讯作者York, Peter; Patterson, Laurence; Zhang, Jiwen
作者单位1.Univ Bradford, Bradford BD7 1DP, W Yorkshire, England;
2.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China;
3.Univ Bradford, Sch Life Sci, Inst Canc Therapeut, Bradford BD7 1DP, W Yorkshire, England;
4.Jiangxi Univ Tradit Chinese Med, Key Lab Modern Preparat Chinese Mat Med, Minist Educ, Nanchang 330004, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Zhen,Yin, Xianzhen,Liu, Congbiao,et al. Microstructural investigation using synchrotron radiation X-ray microtomography reveals taste-masking mechanism of acetaminophen microspheres[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2016,499(1-2):47-57.
APA Guo, Zhen.,Yin, Xianzhen.,Liu, Congbiao.,Wu, Li.,Zhu, Weifeng.,...&Zhang, Jiwen.(2016).Microstructural investigation using synchrotron radiation X-ray microtomography reveals taste-masking mechanism of acetaminophen microspheres.INTERNATIONAL JOURNAL OF PHARMACEUTICS,499(1-2),47-57.
MLA Guo, Zhen,et al."Microstructural investigation using synchrotron radiation X-ray microtomography reveals taste-masking mechanism of acetaminophen microspheres".INTERNATIONAL JOURNAL OF PHARMACEUTICS 499.1-2(2016):47-57.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。