Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting
文献类型：期刊论文
| 作者 | Yin, Xian-Zhen1,2; Wu, Li1,3; Li, Ying1,4; Guo, Tao1; Li, Hai-Yan1 ; Xiao, Ti-Qiao5; York, Peter2; Nangia, Ashwini6; Gui, Shuang-Ying4; Zhang, Ji-Wen1,3,4
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-02-25 |
| 卷号 | 6 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep21770 |
| 文献子类 | Article |
| 英文摘要 | The deformation behavior of particles under pressure dominates the mechanical properties of solid dosage forms. In this study, the in situ 3D deformation of two polymorphs (I and II) of clopidogrel bisulfate (CLP) was determined to illustrate pressure distribution profiles within the tablet by the deformation of the crystalline particles for the first time. Synchrotron radiation X-ray computed microtomography (SR-mu CT) was utilized to visualize and quantify the morphology of thousands crystalline particles of CLP I and CLP II before and after compression. As a result, the deformation was examined across scale dimensions from microns to the size of the final dosage form. Three dimensional parameters such as volume, sphericity, oblate and prolate of individual particle and distributions were computed and analyzed for quantitative comparison to CLP I and CLP II. The different degrees of deformation under the same compression conditions of CLP I and CLP II were observed and characterized quantitatively. The map of deformation degrees within the tablet illustrated the heterogeneous pressure distribution in various regions of the compacted tablet. In conclusion, the polymorph deformation behaviors demonstrated by SR-p,CT quantitative structure analysis deepen understanding of tableting across dimensions from microns to millimeters for the macrostrcuture of tablet. |
| WOS关键词 | X-RAY MICROTOMOGRAPHY ; CONTROLLED-RELEASE KINETICS ; OSMOTIC PUMP TABLETS ; CRYSTAL-STRUCTURE ; DENSITY DISTRIBUTIONS ; MECHANICAL-PROPERTIES ; COMPACTION PROPERTIES ; TOMOGRAPHY |
| 资助项目 | Natural Science Foundation of China[81430087] ; Natural Science Foundation of China[81273453] ; Chinese Academy of Sciences[2011T2S28] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000370788500001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276135]  |
| 专题 | 药物制剂研究中心 分子影像中心（筹） |
| 通讯作者 | Zhang, Ji-Wen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China; 2.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England; 3.Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China; 4.Anhui Univ Chinese Med, Hefei 230038, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China; 6.Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India |
| 推荐引用方式 GB/T 7714 | Yin, Xian-Zhen,Wu, Li,Li, Ying,et al. Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Yin, Xian-Zhen.,Wu, Li.,Li, Ying.,Guo, Tao.,Li, Hai-Yan.,...&Zhang, Ji-Wen.(2016).Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting.SCIENTIFIC REPORTS,6. |
| MLA | Yin, Xian-Zhen,et al."Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting".SCIENTIFIC REPORTS 6(2016). |
入库方式： OAI收割
来源：上海药物研究所
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