Fabrication of non-spherical Pickering emulsion droplets by cyclodextrins mediated molecular self-assembly
文献类型：期刊论文
| 作者 | Wu, Li1,3; Liao, Zuhua3; Liu, Mingqun3; Yin, Xianzhen3; Li, Xue3; Wang, Manli3; Lu, Xiaolong3; Lv, Nana2,3; Singh, Vikramjeet3; He, Zhonggui2 |
| 刊名 | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| 出版日期 | 2016-02-05 |
| 卷号 | 490页码:163-172 |
| 关键词 | Pickering emulsion Non spherical droplet Cyclodextrin Self-assembly Microcrystal |
| ISSN号 | 0927-7757 |
| DOI | 10.1016/j.colsurfa.2015.11.036 |
| 文献子类 | Article |
| 英文摘要 | The unique physiochemical properties of non-spherical carriers play a significant role in their functions and offer distinct advantages as drug delivery systems, including drug loading, stability and targeting. Herein, a simple method to fabricate non-spherical Pickering emulsion droplets (NSPEDs) by cyclodextrins (CDs) mediated molecular self-assembly is reported. The non-spherical shapes controlled by the type and content of oils/CDs were evaluated by the average roundness (R-ave) figures. The stability and physicochemical properties of castor oil (CO)-CDs emulsions, including creaming, viscosity and size distribution with different R-ave values were characterized. The Pickering emulsion droplets with different R-ave values were fabricated through mixing CDs with twelve common oils. The type of oils showed varied dependence of R-ave on the content of oils/CDs. Rave increased when reducing the content of oils or raising the content of CDs. The CO-CDs emulsions with larger Rave exhibited higher creaming index, stronger viscosity, smaller size, and thus possessed better stability. The size distributions at 1 mu m representing the excess oil-CD microcrystals in the continuous phase became larger with increase in R-ave values, indicating that the formation of NSPEDs was mainly ascribed to the excess microcrystals in the emulsions. |
| WOS关键词 | FISH-OIL ; OXIDATIVE STABILITY ; ALPHA-CYCLODEXTRIN ; RELATIVE-HUMIDITY ; COATED DROPLETS ; DRUG-DELIVERY ; NANOPARTICLES ; ENCAPSULATION ; PARTICLES ; ABILITY |
| 资助项目 | National Nature Science Foundation of China[81373358] ; National Nature Science Foundation of China[81273453] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000367233200019 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276150]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang, Jiwen |
| 作者单位 | 1.Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wu, Li,Liao, Zuhua,Liu, Mingqun,et al. Fabrication of non-spherical Pickering emulsion droplets by cyclodextrins mediated molecular self-assembly[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2016,490:163-172. |
| APA | Wu, Li.,Liao, Zuhua.,Liu, Mingqun.,Yin, Xianzhen.,Li, Xue.,...&Zhang, Jiwen.(2016).Fabrication of non-spherical Pickering emulsion droplets by cyclodextrins mediated molecular self-assembly.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,490,163-172. |
| MLA | Wu, Li,et al."Fabrication of non-spherical Pickering emulsion droplets by cyclodextrins mediated molecular self-assembly".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 490(2016):163-172. |
入库方式： OAI收割
来源：上海药物研究所
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