Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers
文献类型：期刊论文
| 作者 | Rao, Yuefeng2,3; Zheng, Feiyue4; Liang, Xingguang2; Wang, Huiyuan1 ; Zhang, Jin2,3; Lu, Xiaoyang2
|
| 刊名 | DRUG DELIVERY
 |
| 出版日期 | 2015-11-17 |
| 卷号 | 22期号:8页码:1003-1009 |
| 关键词 | Drug delivery ethosomes finasteride human cadaver skin in vitro percutaneous permeation liposomes skin distribution |
| ISSN号 | 1071-7544 |
| DOI | 10.3109/10717544.2013.839128 |
| 文献子类 | Article |
| 英文摘要 | The skin accumulation of therapeutic agents affects the efficiency of topical drug delivery. In this study, in vitro distribution of finasteride of ethosomes and liposomes in human cadaver skin after percutaneous delivery were investigated. Experiments were performed using modified Franz diffusion cells. Finasteride ethosomes, liposomes or hydroethanolic solutions were used as donor medium. Drug distribution at different skin layers and depths were studied by hotplate separation and frozen horizontal slicing technique. The result showed that the accumulation of finasteride in skin ranged from 9.7-24.3g/cm(2) at 12 or 24 hours. The ethosomes demonstrated better enhancing ability to deliver finasteride into the dermis layer than liposomes did. The finasteride concentration in the dermis layer from ethosomes was more than sevenfold higher than from liposomes. The finasteride accumulation in ethosomes group showed a distinctive reversed distribution profile. This distinctive reversed distribution profile is meaningful for exerting a favorable pharmacological effect for finasteride. The drug distribution profile in skin layers showed no significant difference between 12 and 24 hours application (p>0.05). The study demonstrated that finasteride can be accumulated at target site more effectively and maintained at higher level through the application of novel ethosomal carriers. |
| WOS关键词 | DRUG-DELIVERY ; TRANSDERMAL DELIVERY ; IN-VITRO ; ETHOSOMES ; TECHNOLOGIES ; PERMEATION ; MECHANISMS ; LIPOSOMES ; VESICLES ; ALOPECIA |
| 资助项目 | National Nature Science Foundation of China[81072231] ; Chinese Postdoctoral Science Foundation[2012M510097] ; Chinese Postdoctoral Science Foundation[2013T60478] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000366272600003 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276319]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Lu, Xiaoyang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Hangzhou, Zhejiang, Peoples R China; 3.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou, Zhejiang, Peoples R China; 4.Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Hangzhou, Zhejiang, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Rao, Yuefeng,Zheng, Feiyue,Liang, Xingguang,et al. Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers[J]. DRUG DELIVERY,2015,22(8):1003-1009. |
| APA | Rao, Yuefeng,Zheng, Feiyue,Liang, Xingguang,Wang, Huiyuan,Zhang, Jin,&Lu, Xiaoyang.(2015).Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers.DRUG DELIVERY,22(8),1003-1009. |
| MLA | Rao, Yuefeng,et al."Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers".DRUG DELIVERY 22.8(2015):1003-1009. |
入库方式： OAI收割
来源：上海药物研究所
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