Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation
文献类型：期刊论文
| 作者 | Zhang, Meng-Qi2; Zhou, Luo2; Deng, Qian-Fang3; Xie, Yuan-Yuan2; Xiao, Ti-Qiao4; Cao, Yu-Ze2; Zhang, Ji-Wen1 ; Chen, Xu-Meng5; Yin, Xian-Zhen1; Xiao, Bo2
|
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015-10-07 |
| 卷号 | 5 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep14982 |
| 文献子类 | Article |
| 英文摘要 | The angioarchitecture is a fundamental aspect of brain development and physiology. However, available imaging tools are unsuited for non-destructive cerebral mapping of the functionally important three-dimensional (3D) vascular microstructures. To address this issue, we developed an ultra-high resolution 3D digitalized angioarchitectural map for rat brain, based on synchrotron radiation phase contrast imaging (SR-PCI) with pixel size of 5.92 mu m. This approach provides a systematic and detailed view of the cerebrovascular anatomy at the micrometer level without any need for contrast agents. From qualitative and quantitative perspectives, the present 3D data provide a considerable insight into the spatial vascular network for whole rodent brain, particularly for functionally important regions of interest, such as the hippocampus, pre-frontal cerebral cortex and the corpus striatum. We extended these results to synchrotron-based virtual micro-endoscopy, thus revealing the trajectory of targeted vessels in 3D. The SR-PCI method for systematic visualization of cerebral microvasculature holds considerable promise for wider application in life sciences, including 3D micro-imaging in experimental models of neurodevelopmental and vascular disorders. |
| WOS关键词 | PHASE-CONTRAST ; HUMAN-BRAIN ; TOMOGRAPHY ; NETWORKS ; MICROSTRUCTURE ; VESSELS ; POINT ; MICE |
| 资助项目 | National Natural Science Foundation of China[81371435] ; National Natural Science Foundation of China[81501025] ; Science Foundation of Xiangya Hospital for Young Scholar[2014Q10] ; Science and Technology Planning Project of Hunan Province, China[2013SK3098] ; Medical Scientific Research Foundation of Hunan Province, China[B2013-032] ; Collaborative Innovation Center for Chemistry and Molecular Medicine[00000000] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000362346900001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276367]  |
| 专题 | 药物制剂研究中心 分子影像中心（筹） |
| 通讯作者 | Xiao, Bo |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China; 2.Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China; 3.Hunan Normal Univ, Xiangdong Hosp, Dept Neurol, Zhuzhou 412200, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China; 5.Hunan Univ Chinese Tradit Med, Dept Pharm, Changsha 410007, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Meng-Qi,Zhou, Luo,Deng, Qian-Fang,et al. Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation[J]. SCIENTIFIC REPORTS,2015,5. |
| APA | Zhang, Meng-Qi.,Zhou, Luo.,Deng, Qian-Fang.,Xie, Yuan-Yuan.,Xiao, Ti-Qiao.,...&Xiao, Bo.(2015).Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation.SCIENTIFIC REPORTS,5. |
| MLA | Zhang, Meng-Qi,et al."Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation".SCIENTIFIC REPORTS 5(2015). |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。