Bioreducible Micelles with Endosomal Buffering and Multidrug Resistance-Reversing Function Enhance Anti-Tumor Efficacy of Doxorubicin
文献类型：期刊论文
| 作者 | Yin, Qi ; Shen, Jianan; Yu, Haijun; Huang, Yongzhuo; Zhang, Zhiwen; Li, Yaping
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| 刊名 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
 |
| 出版日期 | 2015-10 |
| 卷号 | 11期号:10页码:1764-1775 |
| 关键词 | Bioreducible Doxorubicin Endosomal Buffering Micelle Multidrug Resistance |
| ISSN号 | 1550-7033 |
| DOI | 10.1166/jbn.2015.2004 |
| 文献子类 | Article |
| 英文摘要 | The clinical success of anthracyclines-containing chemotherapy for breast cancer is mainly restricted by cardiac damage and the development of multidrug resistance (MDR). For efficient reversal of drug resistance, doxorubicin (DOX) loaded multifunctional bioreducible micelles were constructed from a new amphiphilic copolymer consisting of polyethylene glycol and poly[bis(2-hydroxylethyl)-disulfide-diacrylate-beta-histamine] and characterized. The introduction of imidazole group endowed the micelles with endosomal buffering capacity and improved the endosomal escape. The reduction-responsiveness of the micelles promoted DOX release. The activity of P-glycoprotein, one of the most well-described drug-efflux pumps, and glutathione S-transferase, an important detoxification enzyme, were also inhibited by the micelles. The accumulation of DOX in tumor after intravenous administration of the drug-loading micelles was increased in drug resistant tumor-bearing mice. These results indicated that the micelle was a promising drug delivery system for MDR cancer therapy. |
| WOS关键词 | SOLID LIPID NANOPARTICLES ; DRUG-DELIVERY-SYSTEM ; BREAST-CANCER ; GENE DELIVERY ; IN-VIVO ; THERAPY ; POLYMERS ; CELLS ; BIODISTRIBUTION ; NANOMEDICINE |
| 资助项目 | National Basic Research Program of China[2010CB934000] ; National Basic Research Program of China[2013CB932704] ; National Basic Research Program of China[2013CB932503] ; National Natural Science Foundation of China[81230029] ; National Natural Science Foundation of China[81302712] ; National Natural Science Foundation of China[81102388] ; Shanghai Program[11nm0505900] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000359391800006 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276392]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Huang, Yongzhuo |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Qi,Shen, Jianan,Yu, Haijun,et al. Bioreducible Micelles with Endosomal Buffering and Multidrug Resistance-Reversing Function Enhance Anti-Tumor Efficacy of Doxorubicin[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2015,11(10):1764-1775. |
| APA | Yin, Qi,Shen, Jianan,Yu, Haijun,Huang, Yongzhuo,Zhang, Zhiwen,&Li, Yaping.(2015).Bioreducible Micelles with Endosomal Buffering and Multidrug Resistance-Reversing Function Enhance Anti-Tumor Efficacy of Doxorubicin.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,11(10),1764-1775. |
| MLA | Yin, Qi,et al."Bioreducible Micelles with Endosomal Buffering and Multidrug Resistance-Reversing Function Enhance Anti-Tumor Efficacy of Doxorubicin".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 11.10(2015):1764-1775. |
入库方式： OAI收割
来源：上海药物研究所
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