Automatic monitoring and quantitative characterization of sedimentation dynamics for non-homogenous systems based on image profile analysis
文献类型：期刊论文
| 作者 | Lu, Xiaolong1,5; Liao, Zuhua5,6; Li, Xue5; Wang, Manli5,8; Wu, Li4,5; Li, Haiyan5 ; York, Peter5,7; Xu, Xu3; Yin, Xianzhen5,7; Zhang, Jiwen2,5
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| 刊名 | POWDER TECHNOLOGY
 |
| 出版日期 | 2015-09 |
| 卷号 | 281页码:49-56 |
| 关键词 | Non-homogeneous system Derivative mutation algorithm Automatic monitoring Image processing Sedimentation dynamics Suspensions |
| ISSN号 | 0032-5910 |
| DOI | 10.1016/j.powtec.2015.04.080 |
| 文献子类 | Article |
| 英文摘要 | Sedimentation of non-homogeneous systems is the typical phenomenon indicating the physical instability as a key measure to the quality control of the preparation products. Currently, the determination methods for the sedimentation of non-homogeneous preparations are based on manual measurement or semi-quantitative observation, lacking of either automation or quantitative dynamic analysis. The purpose of this research was to realize automatic and quantitative monitoring of the sedimentation dynamics for non-homogenous systems as suspension, emulsions at laboratory level. Non-contact measurement method has been established to determine the sedimentation behaviors in a standard quartz tube for sedimentation, with internal diameter and height 23 mm and 215 mm, respectively, with controlled temperature and light intensity. As high performance camera has been equipped, the sedimentation images with high spatial and temporal resolution could be acquired, which can continuously capture sedimentation images with the resolution of 2048 x 2048 pixel at a maximum rate of 60 slides/s. All the pictures were processed to extract the luminance matrix top-down along the fixed vertical midline of each picture, which implied sedimentation characteristics of the system at the moment the picture was taken. Combining all the luminance matrixes along vertical middle lines of the pictures, a time-luminance matrix profile was obtained. Digital image processing techniques were used to eliminate interference and establish a three-dimensional surface model of the sedimentation dynamics. Then, the derivative mutation algorithm has been developed for the intelligent identification of sedimentation interface with threshold optimization so as to quantitatively analyze the sedimentation dynamics with visualization. The sedimentation curve and sedimentation dynamic equation of the non-homogeneous system were finally outputted by numerical fitting. The methodology was validated for great significance in determinations of small volume samples, parallel control multiple batches, and long period of time automatic measurement. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS关键词 | LEVEL MEASURING SYSTEM ; BEER-LAMBERT LAW ; ACTIVATED-SLUDGE ; SETTLING VELOCITY ; PHYSICAL STABILITY ; TREATMENT PLANTS ; EMULSIONS ; SUSPENSIONS ; SIZE ; NANOPARTICLES |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:000356996000007 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276429]  |
| 专题 | 分子影像中心（筹） 药物制剂研究中心 |
| 通讯作者 | Xu, Xu |
| 作者单位 | 1.Shanghai Inst Technol, Sch Mech Engn, Shanghai 201418, Peoples R China; 2.Shanghai Inst Technol, Shanghai 201418, Peoples R China; 3.Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China; 4.Jilin Univ, Res Ctr Drug Metab, Changchun 130012, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China; 6.Jiangxi Univ Tradit Chinese Med, Sch Pharm, Nanchang 330004, Peoples R China; 7.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England; 8.Anhui Univ Chinese Med, Sch Pharm, Hefei 230038, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Lu, Xiaolong,Liao, Zuhua,Li, Xue,et al. Automatic monitoring and quantitative characterization of sedimentation dynamics for non-homogenous systems based on image profile analysis[J]. POWDER TECHNOLOGY,2015,281:49-56. |
| APA | Lu, Xiaolong.,Liao, Zuhua.,Li, Xue.,Wang, Manli.,Wu, Li.,...&Zhang, Jiwen.(2015).Automatic monitoring and quantitative characterization of sedimentation dynamics for non-homogenous systems based on image profile analysis.POWDER TECHNOLOGY,281,49-56. |
| MLA | Lu, Xiaolong,et al."Automatic monitoring and quantitative characterization of sedimentation dynamics for non-homogenous systems based on image profile analysis".POWDER TECHNOLOGY 281(2015):49-56. |
入库方式： OAI收割
来源：上海药物研究所
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