Highly efficient ablation of metastatic breast cancer using ammonium-tungsten-bronze nanocube as a novel 1064 nm-laser-driven photothermal agent
文献类型：期刊论文
| 作者 | Guo, Chongshen1; Yu, Haijun2 ; Feng, Bing2; Gao, Weidong2; Yan, Mei1; Zhang, Zhiwen2; Li, Yaping2; Liu, Shaoqin1
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| 刊名 | BIOMATERIALS
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| 出版日期 | 2015-06 |
| 卷号 | 52页码:407-416 |
| 关键词 | Photothermal ablation therapy Cancer Metastasis Tungsten bronze |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2015.02.054 |
| 文献子类 | Article |
| 英文摘要 | Photothermal ablation (PTA) therapy has been viewed as an invasive option for cancer therapy with minimal deconstruction of healthy tissues. In this study, a potent candidate of (NH4)(x)NO3 nanocube was developed for PTA treatment of metastatic breast cancer in the second near-infrared (NIR) window. It was found that the as-synthesized (NH4)(x)WO3 nanocube had significant photoabsorption across the whole NIR window of 780-2500 nm and exhibited considerable photo-heat conversion efficiency. Moreover, the as-prepared (NH4)xWO(3) nanocube displayed good biocompatibility and high cellular uptake efficiency through endocytosis pathway without nuclei entry. The PTA study employing 1064 nm laser in the second NIR window revealed that (NH4)(x)WO3 nanocubes induced significant cell necrosis and apoptosis by producing obviously hyperthermia effect inside cancer cells. Using an orthotopicly implanted breast tumor model, it demonstrated that the (NH4)(x)NO3 nanocube was a promising photothermal agent for effective ablation of solid tumors and suppressing their distant metastasis. (C) 2015 Elsevier Ltd. All rights reserved. |
| WOS关键词 | PEGYLATED W18O49 NANOWIRES ; NEAR-INFRARED ABSORPTION ; CELLS IN-VIVO ; ORGANIC NANOPARTICLES ; SYSTEMIC THERAPY ; CSXWO3 NANORODS ; GOLD NANORODS ; NANOCRYSTALS ; RESISTANCE ; PLATFORM |
| 资助项目 | National Natural Science Foundation of China[21303033] ; National Natural Science Foundation of China[51372054] ; National Natural Science Foundation of China[21161120325] ; National Natural Science Foundation of China[81373359] ; National Basic Research Program of China[2013CB932704] ; Longjiang Scholarship[00000000] ; Outstanding Young Funding of Heilongjiang Province[00000000] ; Fundamental Research Funds for the Central Universities[HIT.NSRIF.2015061] ; Heilngjiang Postdoctoral Financial Assistance[LBH-Z13079] ; China Postdoctoral Science Foundation[2014M551232] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000353091000039 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276517]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Liu, Shaoqin |
| 作者单位 | 1.Harbin Inst Technol, Key Lab Microsyst & Microstruct, Minist Educ, Harbin 150080, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Chongshen,Yu, Haijun,Feng, Bing,et al. Highly efficient ablation of metastatic breast cancer using ammonium-tungsten-bronze nanocube as a novel 1064 nm-laser-driven photothermal agent[J]. BIOMATERIALS,2015,52:407-416. |
| APA | Guo, Chongshen.,Yu, Haijun.,Feng, Bing.,Gao, Weidong.,Yan, Mei.,...&Liu, Shaoqin.(2015).Highly efficient ablation of metastatic breast cancer using ammonium-tungsten-bronze nanocube as a novel 1064 nm-laser-driven photothermal agent.BIOMATERIALS,52,407-416. |
| MLA | Guo, Chongshen,et al."Highly efficient ablation of metastatic breast cancer using ammonium-tungsten-bronze nanocube as a novel 1064 nm-laser-driven photothermal agent".BIOMATERIALS 52(2015):407-416. |
入库方式： OAI收割
来源：上海药物研究所
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